5-Fluoro-2-pyrimidinecarbonitrile
- Product Name
- 5-Fluoro-2-pyrimidinecarbonitrile
- CAS No.
- 38275-55-7
- Chemical Name
- 5-Fluoro-2-pyrimidinecarbonitrile
- Synonyms
- 2-Cyano-5-Fluoropyrimidine;5-fluoropyrimidine-2-carb...;5-fluoro-2-pyrimidinecarbonitrile;5-fluoro-pyrimidine-2-carbonitrile;2-Pyrimidinecarbonitrile, 5-fluoro-;2-Pyrimidinecarbonitrile, 5-fluoro- (9CI);5-Fluoro-2-pyrimidinecarbonitrile ISO 9001：2015 REACH
- CBNumber
- CB41081408
- Molecular Formula
- C5H2FN3
- Formula Weight
- 123.09
- MOL File
- 38275-55-7.mol
5-Fluoro-2-pyrimidinecarbonitrile Property
- Boiling point:
- 255.7±32.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- -4.35±0.22(Predicted)
- Appearance
- brown solid
Safety
- HS Code
- 29335990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596273
- Product name
- 5-Fluoro-2-pyrimidinecarbonitrile
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- PC201244
- Product name
- 5-Fluoro-2-pyrimidinecarbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- W5903
- Product name
- 5-Fluoro-2-pyrimidinecarbonitrile
- Packaging
- 1g
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-M0357
- Product name
- 5-fluoropyrimidine-2-carbonitrile
- Packaging
- 5g
- Price
- $344
- Updated
- 2021/12/16
- Product number
- PC201244
- Product name
- 5-Fluoro-2-pyrimidinecarbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $373
- Updated
- 2021/12/16
5-Fluoro-2-pyrimidinecarbonitrile Chemical Properties,Usage,Production
Chemical Properties
Powder
Synthesis
557-21-1
62802-42-0
38275-55-7
To a 10 mL microwave reaction flask were added 2-chloro-5-fluoropyrimidine (2.0 g, 15.09 mmol), tris(dibenzylideneacetone)dipalladium (Pd2(dba)3, 0.549 g, 0.6 mmol), 1,1'-bis(diphenylphosphino)ferrocene (DPPF, 0.67 g, 1.21 mmol), zinc cyanide (1.15 g, 9.81 mmol) and zinc powder (0.237 mg, 3.62 mmol). The reaction flask was evacuated and displaced three times with nitrogen followed by the addition of anhydrous dimethylacetamide (DMA). The reaction flask was placed in a Personal Chemistry microwave reactor and the reaction was heated at 100 °C for 10 hours. Upon completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc) and washed three times with saturated saline. The organic layer was separated, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The resulting crude product was purified by silica gel column chromatography (ISCO Combiflash system, ethyl acetate/hexane gradient elution) to afford 2-cyano-5-fluoropyrimidine as a milky white solid (1.50 g, 80% yield). The product was analyzed by GC-MS showing molecular ion peak m/z 123 (M+); 1H NMR (CDCl3) δ 8.80 (s, 2H).
References
[1] Patent: WO2006/82392, 2006, A1. Location in patent: Page/Page column 114
[2] Patent: WO2009/7753, 2009, A2. Location in patent: Page/Page column 57
[3] Journal of Medicinal Chemistry, 2008, vol. 51, # 15, p. 4672 - 4684
[4] Patent: WO2007/49041, 2007, A1. Location in patent: Page/Page column 57
[5] Patent: WO2008/117050, 2008, A1. Location in patent: Page/Page column 62
5-Fluoro-2-pyrimidinecarbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Fluoro-2-pyrimidinecarbonitrile manufacturers
- Product
- 5-Fluoro-2-pyrimidinecarbonitrile 38275-55-7
- Price
- US $3.90-5.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-13
- Product
- 5-Fluoro-2-pyrimidinecarbonitrile 38275-55-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-26
- Product
- 5-Fluoro-2-pyrimidinecarbonitrile 38275-55-7
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-28