5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI)
- Product Name
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI)
- CAS No.
- 2227-98-7
- Chemical Name
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI)
- Synonyms
- 9-Deazaadenine;Tenofovir Impurity 114;4-AMino-5H-pyrrolo[3,2-d]...;4-Aminopyrrolo[3,2-d]pyrimidine;1H-pyrrolo[3,2-d]pyriMidin-4-aMine;4-AMino-5H-pyrrolo[3,2-d]pyriMidine;5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI);5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI, ACI);5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) ISO 9001：2015 REACH
- CBNumber
- CB41082076
- Molecular Formula
- C6H6N4
- Formula Weight
- 134.14
- MOL File
- 2227-98-7.mol
5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) Property
- Melting point:
- 235-237 °C
- Boiling point:
- 399.8±22.0 °C(Predicted)
- Density
- 1.480±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 13.84±0.40(Predicted)
- Appearance
- Light yellow to light brown Solid
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P2930
- Product name
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine
- Packaging
- 250MG
- Price
- $210
- Updated
- 2025/07/31
- Product number
- B530340
- Product name
- 5H-pyrrolo[3,2-d]pyrimidin-4-amine
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- CS-0044057
- Product name
- 4-Aminopyrrolo[3,2-d]pyrimidine
- Purity
- 98.69%
- Packaging
- 1g
- Price
- $223
- Updated
- 2021/12/16
- Product number
- 057907
- Product name
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine
- Purity
- 95%
- Packaging
- 1g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 3H30-1-EF
- Product name
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) Chemical Properties,Usage,Production
Synthesis
2320-75-4
2227-98-7
Ethyl 4-amino-5-cyano-1H-pyrrole-3-carboxylate (42.62 g, 207 mmol) was added potassium hydroxide (34.1 g, 517 mmol) to its aqueous (500 ml) suspension and the reaction was carried out at reflux for 24 hours. After completion of the reaction, the mixture was cooled to room temperature, concentrated under vacuum and subsequently resuspended in water (100 ml). The resulting suspension was filtered and the brown solid was collected, washed sequentially with water (50 ml) and ether (100 ml), and dried over air to give 9-deazaadenine (18 g, 65% yield) as a brown solid. Melting point >300°C. 1H NMR (500MHz, d6-DMSO) δ 8.12 (s, 1H), 7.51 (brd, J=2.1Hz, 1H), 6.36 (brd, J=2.1Hz, 1H). 13C NMR (125MHz, d6-DMSO) δ 150.4,150.3,147.2,127.8 ,113.6,101.2.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 17, p. 5326 - 5333
[2] Patent: WO2014/73989, 2014, A1. Location in patent: Page/Page column 24; 34; 35
5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) Preparation Products And Raw materials
Raw materials
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View Lastest Price from 5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) manufacturers
- Product
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) 2227-98-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-13
- Product
- 5H-Pyrrolo[3,2-d]pyrimidin-4-amine (9CI) 2227-98-7
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-03