N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE Property

Boiling point:

167 °C / 5mmHg

Density 

1.01

refractive index 

1.4700-1.4740

Flash point:

147 °C

storage temp. 

2-8°C

form 

clear liquid

pka

15.03±0.10(Predicted)

color 

Light yellow to Amber to Dark green

Stability:

Stability

EPA Substance Registry System

4-(Butylnitrosoamino)butanol (3817-11-6)

Safety

Hazard Codes 

T

Risk Statements 

45-22

Safety Statements 

53

WGK Germany 

3

RTECS 

EL1225000

HS Code 

2929.90.5090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H350May cause cancer

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

N-N-BUTYL-N-BUTAN-4-OL-NITROSAMINE Chemical Properties,Usage,Production

Chemical Properties

red liquid

Uses

N-Butyl-N-(4-hydroxybutyl)nitrosamine (BBN), a carcinogen, is used to induce histiologically relevant aggressive urinary bladder cancer in animal models.

Definition

ChEBI: A nitrosamine that has butyl and 4-hydroxybutyl substituents. In mice, it causes high-grade, invasive cancers in the urinary bladder, but not in any other tissues.

General Description

Dark red liquid.

Air & Water Reactions

Water soluble.

Reactivity Profile

A hydroxylated and nitrated amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Biochem/physiol Actions

Carcinogen used to induce urinary bladder cancer in animal models. The result of exposure is histologically comparable to human urinary bladder tumorigenesis. Used in chemopreventative studies.