4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE

Product Name: 4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE
CAS No.: 103855-00-1
Chemical Name: 4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE
Synonyms: 4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE;Pyridine, 4-(4-bromophenyl)-1,2,3,6-tetrahydro-, hydrochloride (1:1);4-(4-bromo-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride, 95%min
CBNumber: CB41090828
Molecular Formula: C11H13BrClN
Formula Weight: 274.58462
MOL File: 103855-00-1.mol

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4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE Property

storage temp.: Inert atmosphere,Room Temperature

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B701300
Product name: 4-(4-Bromophenyl)-1,2,3,6-tetrahydropyridinehydrochloride
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: 2481AJ
Product name: 4-(4-Bromo-phenyl)-1,2,3,6-tetrahydro-pyridinehydrochloride
Packaging: 1g
Price: $131
Updated: 2021/12/16

AK Scientific

Product number: 2481AJ
Product name: 4-(4-Bromo-phenyl)-1,2,3,6-tetrahydro-pyridinehydrochloride
Packaging: 5g
Price: $311
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0104376
Product name: 4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE HYDROCHLORIDE
Purity: 97.00%
Packaging: 5MG
Price: $498.59
Updated: 2021/12/16

AK Scientific

Product number: 2481AJ
Product name: 4-(4-Bromo-phenyl)-1,2,3,6-tetrahydro-pyridinehydrochloride
Packaging: 10g
Price: $524
Updated: 2021/12/16

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4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE Chemical Properties,Usage,Production

Synthesis

213480-97-8

103855-00-1

General procedure for the synthesis of 4-(4-bromophenyl)piperidin-4-ol hydrochloride from 4-(4-bromophenyl)-1,2,3,6-tetrahydropyridine hydrochloride: 4-(4-bromophenyl)piperidin-4-ol hydrochloride (600 mg, 2.34 mmol) was mixed with 6 M aqueous hydrochloric acid (15 mL) and heated to reflux for 5 hours. After completion of the reaction, the mixture was cooled to room temperature and allowed to stand overnight. The precipitated crystals were collected by filtration, washed sequentially with water and ether, and dried under vacuum to afford the target product 4-(4-bromophenyl)-1,2,3,6-tetrahydropyridine hydrochloride (434 mg, 68% yield) as a white solid with a melting point of 249-251°C. The product was then dried under vacuum. NMR hydrogen spectrum (CD3OD) δH: 7.54 (d, J=8.5 Hz, 2H, H3', H5'), 7.8 (d, J=8.5 Hz, 2H, H2', H6'), 6.20 (br s, 1H, H5), 3.88-3.83 (m, 2H, H6), 3.48 (dd, J=6 Hz, 2H, H2), 2.85- 2.76 (m, 2H, H3). NMR carbon spectrum (CD3OD) δC: 139.5 (Cq), 136.0 (Cq), 132.8 (CH), 128.0 (CH), 123.0 (Cq), 117.9 (CH), 43.4 (CH2), 42.1 (CH2), 24.7 (CH2). High performance liquid chromatography (HPLC) analysis showed a purity of 99.3% with a retention time (tR) of 6.50 min (isocratic conditions, 40% B); 99.2% with a tR of 9.66 min (gradient conditions). High resolution mass spectrometry (HRMS) calculated value C11H13BrN+ [M+H]+: 238.0226, measured value: 238.0235.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 7, p. 2560 - 2564

4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE Suppliers

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103855-00-1, 4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDERelated Search:

4-(4-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride 4-(4-CHLOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 4-(3-(Trifluoromethyl)phenyl)-1,2,3,6-tetrahydropyridine hydrochloride 4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE 1,2,3,6-Tetrahydro-4-phenyl-pyridine 4-(4-BROMO-PHENYL)-1,2,3,6-TETRAHYDRO-PYRIDINE

Pyridine, 4-(4-bromophenyl)-1,2,3,6-tetrahydro-, hydrochloride (1:1)

4-(4-BROMOPHENYL)-1,2,3,6-TETRA HYDROPYRIDINE HYDROCHLORIDE

4-(4-bromo-phenyl)-1,2,3,6-tetrahydro-pyridine hydrochloride, 95%min

103855-00-1

C11H13BrClN