3-BROMO-2-METHOXYBENZALDEHYDE
- Product Name
- 3-BROMO-2-METHOXYBENZALDEHYDE
- CAS No.
- 88275-87-0
- Chemical Name
- 3-BROMO-2-METHOXYBENZALDEHYDE
- Synonyms
- 3-BROMO-2-METHOXYBENZALDEHYDE;Benzaldehyde, 3-bromo-2-methoxy-
- CBNumber
- CB41092589
- Molecular Formula
- C8H7BrO2
- Formula Weight
- 215.04
- MOL File
- 88275-87-0.mol
3-BROMO-2-METHOXYBENZALDEHYDE Property
- Boiling point:
- 282.3±20.0 °C(Predicted)
- Density
- 1.522±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- solid
- Appearance
- Light brown to white Solid
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
N-Bromosuccinimide Price
- Product number
- B694570
- Product name
- 3-Bromo-2-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- FB139558
- Product name
- 3-Bromo-2-methoxybenzaldehyde
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- FB139558
- Product name
- 3-Bromo-2-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $109
- Updated
- 2021/12/16
- Product number
- FB139558
- Product name
- 3-Bromo-2-methoxybenzaldehyde
- Packaging
- 2g
- Price
- $189
- Updated
- 2021/12/16
- Product number
- 2615-9-34
- Product name
- 3-Bromo-2-methoxybenzaldehyde
- Packaging
- 1g
- Price
- $192
- Updated
- 2021/12/16
3-BROMO-2-METHOXYBENZALDEHYDE Chemical Properties,Usage,Production
Synthesis
1829-34-1
74-88-4
88275-87-0
GENERAL STEPS: 3-Bromo-2-hydroxybenzaldehyde (5.0 g, 24.87 mmol) was dissolved in acetone (200 mL) and iodomethane (5.3 g, 37.34 mmol) and potassium carbonate (5.2 g, 37.63 mmol) were added sequentially. The reaction mixture was heated to 60 °C and stirred for 2 hours. After completion of the reaction, the mixture was cooled to room temperature and filtered to remove insoluble solids. The filtrate was concentrated to dryness by rotary evaporation and the resulting residue was redissolved in ethyl acetate. The organic phase was washed with saturated aqueous sodium bicarbonate and subsequently dried over anhydrous magnesium sulfate. After filtration to remove the desiccant, the filtrate was concentrated to give the crude product. The crude product was purified by silica gel column chromatography using 50% ethyl acetate in hexane solution as eluent. The eluate containing the target product was collected and concentrated to give 3-bromo-2-methoxybenzaldehyde (2.0 g, 93% yield) as a colorless slurry. Mass spectrometry analysis showed m/z 215.0 ([M+H]+); the high performance liquid chromatography retention time (HPLC rt) was 13.8 min [a].
References
[1] Patent: WO2013/10904, 2013, A1. Location in patent: Page/Page column 65
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 17, p. 3573 - 3575
[3] Patent: WO2011/33265, 2011, A1. Location in patent: Page/Page column 93-94
[4] Patent: WO2009/76602, 2009, A1. Location in patent: Page/Page column 161-162
[5] Synthesis (Germany), 2018, vol. 50, # 13, p. 2516 - 2522
3-BROMO-2-METHOXYBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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