2,6-Dimethyl-pyridine-4-boronic acid
- Product Name
- 2,6-Dimethyl-pyridine-4-boronic acid
- CAS No.
- 846548-44-5
- Chemical Name
- 2,6-Dimethyl-pyridine-4-boronic acid
- Synonyms
- (2,6-DiMethylpyridin-4-yl)boronic acid;(2,6-Dimethylpyridin-4-yl);2,6-Dimethylpyridin-4-boronic acid;2,6-Dimethyl-pyridine-4-boronic acid;6-diMethylpyridin-4-yl-4-boronic acid;2,6-diMethylpyridin-4-yl-4-boronic acid;B-(2,6-dimethyl-4-pyridinyl)-Boronic acid;Boronic acid, B-(2,6-dimethyl-4-pyridinyl)-;(2,6-dimethylpyridin-4-yl)boronic acid - [D25621]
- CBNumber
- CB41113127
- Molecular Formula
- C7H10BNO2
- Formula Weight
- 150.97
- MOL File
- 846548-44-5.mol
2,6-Dimethyl-pyridine-4-boronic acid Property
- Boiling point:
- 316.9±52.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 7.72±0.11(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H10BNO2/c1-5-3-7(8(10)11)4-6(2)9-5/h3-4,10-11H,1-2H3
- InChIKey
- ALGDKINLACWIRM-UHFFFAOYSA-N
- SMILES
- B(C1C=C(C)N=C(C)C=1)(O)O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- D479760
- Product name
- 2,6-Dimethyl-4-pyridylboronicAcid
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- D479760
- Product name
- 2,6-Dimethyl-4-pyridylboronicAcid
- Packaging
- 5g
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- CS-W023096
- Product name
- Boronicacid,B-(2,6-dimethyl-4-pyridinyl)-
- Purity
- >97.0%
- Packaging
- 250mg
- Price
- $68
- Updated
- 2021/12/16
- Product number
- FD142545
- Product name
- (2,6-Dimethylpyridin-4-yl)boronic acid
- Packaging
- 50mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- CS-W023096
- Product name
- Boronicacid,B-(2,6-dimethyl-4-pyridinyl)-
- Purity
- >97.0%
- Packaging
- 1g
- Price
- $124
- Updated
- 2021/12/16
2,6-Dimethyl-pyridine-4-boronic acid Chemical Properties,Usage,Production
Uses
2,6-Dimethyl-4-pyridylboronic Acid is used to synthesize isothiazolopyridones with antibacterial activity.
Synthesis
5093-70-9
5419-55-6
846548-44-5
The general procedure for the synthesis of 2,6-dimethyl-pyridine-4-boronic acid from 4-bromo-2,6-dimethylpyridine and triisopropyl borate was as follows: in a dry reaction flask, 4-bromo-2,6-dimethylpyridine (100 mg, 0.54 mmol) and triisopropyl borate (149 μL, 0.65 mmol) were dissolved in anhydrous THF (5 mL). The reaction system was cooled to -78 °C under nitrogen protection, followed by the slow dropwise addition of a hexane solution of 2.5 M n-BuLi (0.26 mL, 0.65 mmol). After the dropwise addition, the reaction was kept at -78 °C for 30 min. Subsequently, the reaction mixture was slowly warmed to room temperature and stirring was continued for 1 hour. After completion of the reaction, 1 N HCl (5 mL) was added to the reaction system and stirred for 30 min at room temperature. Next, the reaction solution was adjusted to alkaline (pH ~9) with 1 N NaOH and then extracted with EtOAc (3 × 10 mL). The organic phases were combined, dried with anhydrous Na2SO4, filtered and concentrated under reduced pressure to afford 2,6-dimethyl-pyridine-4-boronic acid (30.0 mg, 0.20 mmol, 37% yield) as a white solid.
References
[1] Patent: WO2016/196644, 2016, A1. Location in patent: Paragraph 243; 244
[2] Patent: WO2018/102452, 2018, A2. Location in patent: Paragraph 227; 228
2,6-Dimethyl-pyridine-4-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dimethyl-pyridine-4-boronic acid Suppliers
- Tel
- 13052276172
- Fax
- 13052276172
- product@yuyuanpharm.com
- Country
- China
- ProdList
- 494
- Advantage
- 55
- Tel
- 025-66113011 17714375163
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19906
- Advantage
- 55
- Tel
- 150-2103-5486 18017383231
- Fax
- qq：2817624287
- 983544897@qq.com
- Country
- China
- ProdList
- 9341
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- 0411-62313318 13942603642
- Fax
- 0411-87549748
- info@allychem.com
- Country
- China
- ProdList
- 1022
- Advantage
- 65
- Tel
- 18151128828
- Fax
- -
- hc-sales@foxmail.com
- Country
- China
- ProdList
- 2645
- Advantage
- 55
- Tel
- 400-400-164-7117 18317119277
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39999
- Advantage
- 60
- Tel
- 0571-87396432
- Fax
- 0571-87396431
- sales@jhechem.com
- Country
- China
- ProdList
- 14917
- Advantage
- 59
View Lastest Price from 2,6-Dimethyl-pyridine-4-boronic acid manufacturers
- Product
- 2,6-Dimethyl-pyridine-4-boronic acid 846548-44-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95-99%
- Supply Ability
- 1ton
- Release date
- 2019-12-31