ChemicalBook > CAS DataBase List > 4-Bromo-3-chloro-6-methoxyaniline
4-Bromo-3-chloro-6-methoxyaniline
- Product Name
- 4-Bromo-3-chloro-6-methoxyaniline
- CAS No.
- 102170-53-6
- Chemical Name
- 4-Bromo-3-chloro-6-methoxyaniline
- Synonyms
- 4-Bromo-3-chloro-6-methoxyaniline;4-BroMo-5-chloro-2-Methoxyaniline;4-Bromo-5-chloro-2-methoxyaniline 95+%;Benzenamine, 4-bromo-5-chloro-2-methoxy-
- CBNumber
- CB41113839
- Molecular Formula
- C7H7BrClNO
- Formula Weight
- 236.49
- MOL File
- Mol file
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4-Bromo-3-chloro-6-methoxyaniline Property
- Boiling point:
- 296.7±35.0 °C(Predicted)
- Density
- 1.643±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.78±0.10(Predicted)
- Appearance
- Light brown to black Solid
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Safety
- HS Code
- 2921420090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H227Combustible liquid
H302Harmful if swallowed
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- B679135
- Product name
- 4-Bromo-5-chloro-2-methoxyaniline
- Packaging
- 2.5g
- Price
- $140
- Updated
- 2021/12/16
TRC
- Product number
- B679135
- Product name
- 4-Bromo-5-chloro-2-methoxyaniline
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
Apolloscientific
- Product number
- OR54520
- Product name
- 4-Bromo-5-chloro-2-methoxyaniline
- Purity
- 95+%
- Packaging
- 25g
- Price
- $304
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4656-D-21
- Product name
- 4-Bromo-5-chloro-2-methoxyaniline
- Packaging
- 25g
- Price
- $360
- Updated
- 2021/12/16
American Custom Chemicals Corporation
- Product number
- HCH0358781
- Product name
- 4-BROMO-3-CHLORO-6-METHOXY ANILINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.61
- Updated
- 2021/12/16
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4-Bromo-3-chloro-6-methoxyaniline Chemical Properties,Usage,Production
Uses
4-Bromo-5-chloro-2-methoxyaniline is a versatile reactant used in the preparation of thiazole and thiophene derivatives as store-operated calcium channels modulators useful in treatment of SOC channel-mediated diseases.
Synthesis
95-03-4
102170-53-6
General procedure for the synthesis of 4-bromo-5-chloro-2-methoxyaniline from 4-chloro-2-aminoanisole: N-bromosuccinimide (86.7 g, 0.487 mol) was added in batches to a solution of 5-chloro-2-methoxyaniline (Intermediate 5, 76.7 g, 0.487 mol) in acetonitrile (500 mL) at 0 °C, and the addition process lasted for 2 hours. After completion of the addition, the solvent was removed by distillation under reduced pressure. The residue was purified by column chromatography (silica gel: 200-300 mesh, 200 g) with petroleum ether/ethyl acetate as eluent (ratio tapered from 20:1 to 4:1) to afford 4-bromo-5-chloro-2-methoxyaniline as a light yellow solid (40.2 g, 35% yield). The product was analyzed by LCMS (A): retention time (Rt) 1.63 min, molecular ion peak (MH+) m/z 236/238. 1H NMR (300 MHz, CDCl3) δ 6.93 (s, 1H), 6.78 (s, 1H), 3.83 (s, 3H).
References
[1] Patent: WO2015/91647, 2015, A1. Location in patent: Page/Page column 41; 42
[2] Patent: WO2016/188827, 2016, A1. Location in patent: Page/Page column 21
4-Bromo-3-chloro-6-methoxyaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-3-chloro-6-methoxyaniline manufacturers
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 4-Bromo-3-chloro-6-methoxyaniline 102170-53-6
- Price
- US $10.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-11-06
Henan Bao Enluo International TradeCo.，LTD
- Product
- 4-Bromo-3-chloro-6-methoxyaniline 102170-53-6
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99.9%
- Supply Ability
- 10000MT
- Release date
- 2023-08-08