Foropafant

Product Name: Foropafant
CAS No.: 136468-36-5
Chemical Name: Foropafant
Synonyms: SR 27417;Faropafant;Foropafant;SR 27417 >=98% (HPLC);Foropafant, 10 mM in DMSO;inhibit,SR-27417,SR 27417,Foropafant,Inhibitor;N-(2-Dimethylaminoethyl)-N-(3-pyridylmethyl)-4-(2,4,6-triisopropylphenyl)thiazol-2-amine;4-(2,4,6-Triisopropylphenyl)-N-[2-(dimethylamino)ethyl]-N-(3-pyridylmethyl)thiazol-2-amine;N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2;N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-di
CBNumber: CB41117105
Molecular Formula: C28H40N4S
Formula Weight: 464.71
MOL File: 136468-36-5.mol

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Foropafant Property

Boiling point:: 571.6±60.0 °C(Predicted)
Density: 1.065±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: soluble5mg/mL (clear solution, warmed)
form: powder
pka: 8.75±0.28(Predicted)
color: white to beige
InChI: 1S/C28H40N4S/c1-19(2)23-14-24(20(3)4)27(25(15-23)21(5)6)26-18-33-28(30-26)32(13-12-31(7)8)17-22-10-9-11-29-16-22/h9-11,14-16,18-21H,12-13,17H2,1-8H3
InChIKey: VVBFISAUNSXQGZ-UHFFFAOYSA-N
SMILES: CC(C)c1cc(C(C)C)c(-c2csc(n2)N(CCN(C)C)Cc3cccnc3)c(c1)C(C)C

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Safety

WGK Germany: 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0542
Product name: SR 27417
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $161
Updated: 2026/03/19

Sigma-Aldrich

Product number: SML0542
Product name: SR 27417
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $614
Updated: 2026/03/19

American Custom Chemicals Corporation

Product number: INB0000655
Product name: SR 27417
Purity: 95.00%
Packaging: 5MG
Price: $503.58
Updated: 2021/12/16

Matrix Scientific

Product number: 097087
Product name: N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-diamine
Purity: 95+%
Packaging: 250mg
Price: $1853
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000655
Product name: SR 27417
Purity: 95.00%
Packaging: 1G
Price: $3780
Updated: 2021/12/16

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Foropafant Chemical Properties,Usage,Production

Uses

Foropafant (SR27417) highly potent, competitive, selective and orally active antagonist of platelet-activating factor (PAF) receptor, with a Ki value of 57 pM for [3H]PAF binding, at least 5-fold lower than that of unlabeled PAF itself. Foropafant potently inhibits PAF-induced aggregation of rabbit and human platelets[1].

Biochem/physiol Actions

SR 27417 is a long-acting, highly potent, specific competitive platelet-activating factor (PAF) receptor antagonist.

References

[1] Herbert JM, et al. Biochemical and pharmacological activities of SR 27417, a highly potent, long-acting platelet-activating factor receptor antagonist. J Pharmacol Exp Ther. 1991 Oct;259(1):44-51. DOI:10.1016/j.ejmech.2019.01.043

Foropafant Preparation Products And Raw materials

Raw materials

Preparation Products

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Foropafant Suppliers

China 31 United States 8 Global 39

ChemFuture PharmaTech (Jiangsu) Ltd

Tel: 5108538618
Fax: 86 510 85386988-8017
Email: suger.wang@chemfuture.com
Country: China
ProdList: 832
Advantage: 65

Hunan Hui Bai Shi Biotechnology Co., Ltd.

Tel: 0731-85526065 13308475853
Email: ivy@hnhbsj.com
Country: China
ProdList: 7245
Advantage: 62

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 86249
Advantage: 60

Chengdu Huachun Technology Co., Ltd

Tel: 400-1166-196 15982826727
Fax: QQ：800101999
Email: cdhxsj@163.com
Country: China
ProdList: 14603
Advantage: 60

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 9505
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Aikon International Limited

Tel: 025-58859352 15955137747
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 16027
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 021-4009004166/18616739031 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52678
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32467
Advantage: 58

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View Lastest Price from Foropafant manufacturers

Speranza Chemical Co., Ltd.

Product: Foropafant 136468-36-5
Price: US $0.00-0.00/KG
Min. Order: 5KG
Purity: 98%
Supply Ability: 25kg
Release date: 2024-01-05

136468-36-5, ForopafantRelated Search:

4-(2,4,6-TRIMETHYL-PHENYL)-THIAZOL-2-YLAMINE 4-(4-ETHYL-PHENYL)-THIAZOL-2-YLAMINE 2-Amino-4-(4-isopropylphenyl)- thiazole Foropafant

Foropafant

4-(2,4,6-Triisopropylphenyl)-N-[2-(dimethylamino)ethyl]-N-(3-pyridylmethyl)thiazol-2-amine

SR 27417

N-(2-Dimethylaminoethyl)-N-(3-pyridylmethyl)-4-(2,4,6-triisopropylphenyl)thiazol-2-amine

N1,N1-dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-diamine

N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2-di

Faropafant

N,N-Dimethyl-N′-(3-pyridinylmethyl)-N′-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine

N1,N1-Dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-1,2-ethanediamine

N1,N1-Dimethyl-N2-(pyridin-3-ylmethyl)-N2-(4-(2,4,6-triisopropylphenyl)thiazol-2-yl)ethane-1,2

1,2-Ethanediamine, N1,N1-dimethyl-N2-(3-pyridinylmethyl)-N2-[4-[2,4,6-tris(1-methylethyl)phenyl]-2-thiazolyl]-

SR 27417 >=98% (HPLC)

inhibit,SR-27417,SR 27417,Foropafant,Inhibitor

Foropafant, 10 mM in DMSO

136468-36-5

C28H40N4S