Guanoxan
- Product Name
- Guanoxan
- CAS No.
- 2165-19-7
- Chemical Name
- Guanoxan
- Synonyms
- Guanoxan;Guanoxane;Guanoxan USP/EP/BP;2-(GuanidinoMethyl)-1,4-benzodioxan;(1,4-Benzodioxan-2-ylmethyl)guanidine;2-(2,3-dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;1-(2,3-Dihydro-1,4-benzodioxin-2-ylmethyl)guanidine;N-[(2,3-Dihydro-1,4-benzodioxin-2-yl)Methyl]guanidine;Guanidine, N-[(2,3-dihydro-1,4-benzodioxin-2-yl)methyl]-
- CBNumber
- CB41117509
- Molecular Formula
- C10H13N3O2
- Formula Weight
- 207.23
- MOL File
- 2165-19-7.mol
Guanoxan Property
- Melting point:
- 164-165°
- Boiling point:
- 339.3±45.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- pka
- pKa 12.3 (Uncertain)
N-Bromosuccinimide Price
- Product number
- API0011596
- Product name
- GUANOXAN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 58482
- Product name
- Guanoxan
- Packaging
- 10mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- API0011596
- Product name
- GUANOXAN
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $750.75
- Updated
- 2021/12/16
- Product number
- API0011596
- Product name
- GUANOXAN
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1963.5
- Updated
- 2021/12/16
Guanoxan Chemical Properties,Usage,Production
Originator
Envacar,Pfizer
Uses
Guanoxan is a sympatholytic drug related to Guanethidine (G815000). Guanoxan is used in the treatment of hypertension.
Definition
ChEBI: Guanoxan is a benzodioxine.
Manufacturing Process
2 Methods of producing of 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine:
1. 3.3 parts by weight of 2-aminomethyl-1,4-benzodioxane and 2.78 parts by
weight of S-methylisothiouronium sulfate were dissolved in 20 parts by
volume of water, and the resulting aqueous solution was heated under reflux
for 3 h. At the end of this time, the solvent was removed by means of
evaporation under reduced pressure and the residue so obtained dissolved in
a minimum amount of fresh water and treated with charcoal. Upon filtration,
there was obtained a clear filtrate which, on standing, soon afforded pure
crystals of di(2-guanidinomethyl-1,4-benzodioxane)sulfate, melting point
204°-205°C.
The base 2-guanidinemethyl-2,3-dihydro-1,4-benzodioxine may be obtained
by reaction of di(2-guanidinomethyl-1,4-benzodioxane)sulfate with, for
example, sodium hydroxide.
2. o-Dihydroxybenzene reacted with epichlorhydrine in the presence sodium
hydroxide and 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine was obtained.
To solution of 2-hydroxymethyl-2,3-dihydro-1,4-benzodioxine thionylchloride
was added to give 2-chlormethyl-2,3-dihydro-1,4-benzodioxine.
2-Chloromethyl-2,3-dihydro-1,4-benzodioxine reacted with benzylamine to
produced 2-benzylaminomethyl-2,3-dihydro-1,4-benzodioxine, which was
reduced at the presence of hydrogen and Pd-C (catalyst) to 2-aminomethyl-
2,3-dihydro-1,4-benzodioxine.
2-Aminomethyl-2,3-dihydro-1,4-benzodioxine was treated by Smethylisothiouronium sulfate and there was produced 2-guanidinemethyl-2,3-
dihydro-1,4-benzodioxine.
brand name
Envacar (Pfizer).
Therapeutic Function
Antihypertensive
Guanoxan Preparation Products And Raw materials
Raw materials
Preparation Products
Guanoxan Suppliers
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- 010-82848833 400-666-7788
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View Lastest Price from Guanoxan manufacturers
- Product
- Guanoxan 2165-19-7
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 500 MT
- Release date
- 2020-05-09