Methotrexate
- Product Name
- Methotrexate
- CAS No.
- 91431-42-4
- Chemical Name
- Methotrexate
- Synonyms
- RS4317;Lopalene;RS-43197;RS 43179;Lonapalene;RS4317 (Lonapalene);Lonapalene (RS4317);6-Chloro-2,3-dimethoxy-1,4-naphthalenediol diacetate;1,4-Naphthalenediol, 6-chloro-2,3-dimethoxy-, 1,4-diacetate
- CBNumber
- CB41117776
- Molecular Formula
- C16H15ClO6
- Formula Weight
- 338.74
- MOL File
- 91431-42-4.mol
Methotrexate Property
- Melting point:
- 93-94° (Jones); mp 87.5-89.5° (Perri, Moore)
- Boiling point:
- 424.9±45.0 °C(Predicted)
- Density
- 1.309±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to light yellow
N-Bromosuccinimide Price
- Product number
- CS-7197
- Product name
- Lonapalene
- Purity
- 99.07%
- Packaging
- 1mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- API0008229
- Product name
- LONAPALENE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.9
- Updated
- 2021/12/16
- Product number
- CS-7197
- Product name
- Lonapalene
- Purity
- 99.07%
- Packaging
- 5mg
- Price
- $650
- Updated
- 2021/12/16
Methotrexate Chemical Properties,Usage,Production
Originator
Lonapalene,Syntex
Uses
Antipsoriatic.
Definition
ChEBI: Lonapalene is an organochlorine compound and a member of naphthalenes.
Manufacturing Process
A solution of sodium nitrate (0.69 g, 10 mmol) in water (5 ml) was added at 0-5°C to a solution of 6-amino-2,3-dimethoxy-1,4-naphthoquinone (1.17 g, 5 mmol) in 5:1 acetic acid:water (25 ml) containing concentrated hydrochloric acid (1.7 ml). A further quantity of sodium nitrite (0.69 g) was then added to the reaction mixture after cooling to -5°C, followed by a solution of cuprous chloride (0.6 g) in concentrated hydrochloric acid (5 ml). The mixture was allowed to warm to room temperature and solid cuprous chloride was added portionwise until the mixture assumed a green color. Water was then added to the reaction mixture and the precipitated yellow solid filtered off, washed with water and recrystallized from methanol:water (2:1) giving 1.01 g of 6-chloro- 2,3-dimethoxy-1,4-naphthoquinone, melting point 93-94°C (from etherpetrolium ether).
Therapeutic Function
Antipsoriatic
Methotrexate Preparation Products And Raw materials
Raw materials
Preparation Products
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