2,3-DIFLUORO-4-BROMOBENZALDEHYDE
- Product Name
- 2,3-DIFLUORO-4-BROMOBENZALDEHYDE
- CAS No.
- 644985-24-0
- Chemical Name
- 2,3-DIFLUORO-4-BROMOBENZALDEHYDE
- Synonyms
- 4-Bromo-2,3-fluorobenzaldehyde;2,3-DIFLUORO-4-BROMOBENZALDEHYDE;Benzaldehyde, 4-bromo-2,3-difluoro-;4-Bromo-2,3-difluorobenzaldehyde,98%;4-Bromo-2,3-difluorobenzaldehyde 95+%;2,3-DIFLUORO-4-BROMOBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber
- CB41119710
- Molecular Formula
- C7H3BrF2O
- Formula Weight
- 221
- MOL File
- Mol file
2,3-DIFLUORO-4-BROMOBENZALDEHYDE Property
- Melting point:
- 66-67℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Powder
- color
- Off-white
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C7H3BrF2O/c8-5-2-1-4(3-11)6(9)7(5)10/h1-3H
- InChIKey
- IMOLPSNRLZLWQR-UHFFFAOYSA-N
- SMILES
- C(C1C=CC(Br)=C(F)C=1F)=O
Safety
- HS Code
- 2913000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- PC9172
- Product name
- 4-Bromo-2,3-difluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 2615-B-06
- Product name
- 4-Bromo-2,3-difluorobenzaldehyde
- Purity
- 95.0%
- Packaging
- 1g
- Price
- $36
- Updated
- 2021/12/16
- Product number
- 094508
- Product name
- 4-Bromo-2,3-difluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $48
- Updated
- 2021/12/16
- Product number
- FB105618
- Product name
- 4-bromo-2,3-difluorobenzaldehyde
- Packaging
- 1g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- PC9172
- Product name
- 4-Bromo-2,3-difluorobenzaldehyde
- Purity
- 95+%
- Packaging
- 5g
- Price
- $85
- Updated
- 2021/12/16
2,3-DIFLUORO-4-BROMOBENZALDEHYDE Chemical Properties,Usage,Production
Uses
4-Bromo-2,3-difluorobenzaldehyde is used as pharmaceutical intermediates.
Synthesis
156682-52-9
68-12-2
644985-24-0
1. Preparation of iso-PrMgCl-LiCl complex: LiCl (4.56 g, 107.6 mmol) was placed under high vacuum and dried using a hot air gun for 10 min. Under nitrogen atmosphere, iso-PrMgCl (53.8 mL, 107.6 mmol, 2M THF solution) was added to the dried LiCl, and the reaction mixture was stirred at 23 °C for 3 days to obtain a THF solution of iso-PrMgCl-LiCl complex. 2. Synthesis of 4-bromo-2,3-difluorobenzaldehyde: A THF (5 mL) solution of 1,4-dibromo-2,3-difluorobenzene (1.29 mL, 10 mmol) was slowly added to a solution of the iso-PrMgCl-LiCl complex (5.5 mL, 11 mmol, 2.0 M THF solution) at -40 °C, making sure that the reaction temperature was maintained at below -30 °C . Subsequently, the reaction mixture was stirred at -35 to -30 °C for 1 h. The reaction was then warmed up to -7 °C to continue the reaction for 1 h. The reaction mixture was then cooled to -7 °C to continue the reaction. 3. The reaction mixture was cooled to -30 °C and N,N-dimethylformamide (DMF, 1.00 mL, 13 mmol) was added in a single addition, at which point the temperature rose to -23 °C. The reaction mixture was stirred in the range of -25 to 15 °C for 3.5 hours. 4. Post-treatment: the reaction mixture was poured into a mixture of 1 M H2SO4 and ice, saturated with solid NaCl and extracted twice with methyl tert-butyl ether (MTBE). The organic phases were combined, dried with MgSO4, filtered and concentrated in vacuum to give 4-bromo-2,3-difluorobenzaldehyde (D-1d) 2.17 g in 98% yield as a white solid.
References
[1] Patent: US2008/249151, 2008, A1. Location in patent: Page/Page column 16; 23
[2] Patent: US2009/170856, 2009, A1. Location in patent: Page/Page column 26
[3] Patent: US2006/25462, 2006, A1. Location in patent: Page/Page column 11; 21
[4] Patent: US2006/223874, 2006, A1. Location in patent: Page/Page column 5; 9
[5] Patent: WO2018/75871, 2018, A1. Location in patent: Page/Page column 64-65
2,3-DIFLUORO-4-BROMOBENZALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-DIFLUORO-4-BROMOBENZALDEHYDE manufacturers
- Product
- 4-Bromo-2.3-Difluorobenzaldehyde 644985-24-0
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 ton
- Release date
- 2024-08-21
- Product
- 2,3-DIFLUORO-4-BROMOBENZALDEHYDE 644985-24-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-12