ChemicalBook > CAS DataBase List > Forodesine

Forodesine

Product Name
Forodesine
CAS No.
209799-67-7
Chemical Name
Forodesine
Synonyms
Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
CBNumber
CB41120376
Molecular Formula
C11H14N4O4
Formula Weight
266.25
MOL File
209799-67-7.mol
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Forodesine Property

Boiling point:
613.5±65.0 °C(Predicted)
Density 
2.01
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
solubility 
PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
pka
13.88±0.70(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
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N-Bromosuccinimide Price

Cayman Chemical
Product number
30475
Product name
Forodesine
Packaging
1mg
Price
$36
Updated
2023/06/20
Cayman Chemical
Product number
30475
Product name
Forodesine
Packaging
25mg
Price
$308
Updated
2023/06/20
Cayman Chemical
Product number
30475
Product name
Forodesine
Packaging
5mg
Price
$159
Updated
2023/06/20
Cayman Chemical
Product number
30475
Product name
Forodesine
Packaging
10mg
Price
$194
Updated
2023/06/20
TRC
Product number
F754540
Product name
Fodosine
Packaging
1mg
Price
$55
Updated
2021/12/16
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Forodesine Chemical Properties,Usage,Production

Description

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Uses

Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.

Definition

ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.

Forodesine Preparation Products And Raw materials

Raw materials

Preparation Products

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Forodesine Suppliers

China 35 India 3 South Korea 1 United States 8 Global 47
NCE Biomedical Co.,Ltd.
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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+86-27-87599188
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China
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UHN Shanghai Research & Development Co., Ltd.
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021-58958002 18930822973
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+86 (21) 5895-8628
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SALES@UHNSHANGHAI.COM
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Shanghai Xingui Biotechnology Co., Ltd.
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17501653715
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xingui2022@126.com
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China
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SPIRO PHARMA
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Amadis Chemical Company Limited
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sales@amadischem.com
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Shanghai Biopharmaleader Co., Ltd.
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Wuhan NewBaiChuan Pharmaceutical Co., Ltd.
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Wuhan Xinbaichuan Pharmaceutical Technology Co., Ltd.
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Hangzhou Synstar pharmaceutical Technology CO.,Ltd
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0571-85361029
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synstar518@163.com
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NewCan Biotech Limited
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+86-0571-86912261 +8613735419629
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Hefei TNJ Chemical Industry Co.,Ltd.
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Hefei Hirisun Pharmatech Co., Ltd
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Baoji Guokang Bio-Technology Co., Ltd.
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CONIER CHEM AND PHARMA LIMITED
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Absin Bioscience Inc.
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Advanced chemblocks inc
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sales@achemblock.com
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Henan Weitesi Chemical Technology Co. LTD
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Hangzhou FuRun Pharmaceutical Technology Co., Ltd
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Jiangsu Nanchuang Chemical and Life Health Research Institute Co., Ltd.
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15720605021
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TargetMol Chemicals Inc.
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Shanghai Tachizaki Biomedical Research Center
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Hubei Enxing Biotechnology Co., Ltd
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Nantong QuanYi Biotechnology Co., Ltd
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Shanghai Yifei Biotechnology Co. , Ltd.
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PharmaBlock Sciences (Nanjing), Inc.
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RD International Technology Co., Limited
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Suzhou ARTK Medchem Co., Ltd.
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Shanghai Hao Biological Technology Co., Ltd.
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Shanghai Yuda Industrial Co., Ltd.
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Shanghai Zhenyu Biological Technology Co., Ltd.
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Atomax Chemicals Co., Ltd
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View Lastest Price from Forodesine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Forodesine 209799-67-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Forodesine 209799-67-7
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-08

209799-67-7, ForodesineRelated Search:

Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Povidone iodine 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Forodesine METHYL-2-PYRROLIDONE

  • Isopamphos
  • 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-
  • Forodesine
  • 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
  • Fodosine
  • Immucillin-H
  • (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H
  • FORODESINE FODOSINE
  • 4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro-
  • BCX-1777 freebase
  • (1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride
  • 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
  • 209799-67-7