Forodesine

ChemicalBook > CAS DataBase List > Forodesine

Product Name: Forodesine
CAS No.: 209799-67-7
Chemical Name: Forodesine
Synonyms: Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
CBNumber: CB41120376
Molecular Formula: C11H14N4O4
Formula Weight: 266.25
MOL File: 209799-67-7.mol

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Forodesine Property

Boiling point:: 613.5±65.0 °C(Predicted)
Density: 2.01
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: PBS (pH 7.2): 5 mg/ml
form: A crystalline solid
pka: 13.88±0.70(Predicted)
color: Light brown to gray

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 30475
Product name: Forodesine
Packaging: 1mg
Price: $36
Updated: 2023/06/20

Cayman Chemical

Product number: 30475
Product name: Forodesine
Packaging: 25mg
Price: $308
Updated: 2023/06/20

Cayman Chemical

Product number: 30475
Product name: Forodesine
Packaging: 5mg
Price: $159
Updated: 2023/06/20

Cayman Chemical

Product number: 30475
Product name: Forodesine
Packaging: 10mg
Price: $194
Updated: 2023/06/20

TRC

Product number: F754540
Product name: Fodosine
Packaging: 1mg
Price: $55
Updated: 2021/12/16

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Forodesine Chemical Properties,Usage,Production

Description

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC₅₀s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC₅₀s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Uses

Fodosine is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.

Definition

ChEBI: Immucillin H is a pyrrolopyrimidine and a dihydroxypyrrolidine.

Forodesine Preparation Products And Raw materials

Raw materials

Preparation Products

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Forodesine Suppliers

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View Lastest Price from Forodesine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: Forodesine 209799-67-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Forodesine 209799-67-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

209799-67-7, ForodesineRelated Search:

Polyvinylpyrrolidone Crospovidone N-Methyl-2-pyrrolidone N-Vinyl-2-pyrrolidone Povidone iodine 1,5-DIHYDRO-4H-PYRROLO[3,2-D]PYRIMIDIN-4-ONE Forodesine METHYL-2-PYRROLIDONE

Isopamphos

4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-

Forodesine

7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

Fodosine

Immucillin-H

(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H

FORODESINE FODOSINE

4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro-

BCX-1777 freebase

(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride

7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one

209799-67-7