4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine

Product Name: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine
CAS No.: 659729-09-6
Chemical Name: 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine
Synonyms: 4-Chloro-6-(4-(trifluoromethyl);PYRIMIDINE, 4-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]-
CBNumber: CB41120912
Molecular Formula: C11H6ClF3N2
Formula Weight: 258.63
MOL File: 659729-09-6.mol

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4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Property

Boiling point:: 318.7±37.0 °C(Predicted)
Density: 1.385±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: -1.61±0.18(Predicted)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 0122AC
Product name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
Packaging: 100mg
Price: $165
Updated: 2021/12/16

Matrix Scientific

Product number: 097807
Product name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
Purity: 95+%
Packaging: 250mg
Price: $341
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0358919
Product name: 4-CHLORO-6-(4'-(TRIFLUOROMETHYL)PHENYL)PYRIMIDINE
Purity: 95.00%
Packaging: 5MG
Price: $499.55
Updated: 2021/12/16

AK Scientific

Product number: 0122AC
Product name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
Packaging: 1g
Price: $505
Updated: 2021/12/16

Matrix Scientific

Product number: 097807
Product name: 4-Chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine
Purity: 95+%
Packaging: 1g
Price: $756
Updated: 2021/12/16

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4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Chemical Properties,Usage,Production

Synthesis

1193-21-1

128796-39-4

659729-09-6

General procedure: All solvents and solutions used for the reaction are degassed with argon for 15 minutes. Under argon protection, 4,6-dichloropyrimidine (1.5 eq.) was dissolved in THF (1 M) in a round bottom flask. Subsequently, 4-trifluoromethylphenylboronic acid (1.0 eq.), palladium acetate (0.02 eq., 2 mol%), triphenylphosphine (0.04 eq., 4 mol%), and 1M aqueous Na2CO3 solution (2.0 eq.) were added. The reaction mixture was stirred at 60°C overnight. After completion of the reaction, it was cooled to room temperature and extracted with an aqueous layer and Et2O. The organic layers were combined, washed with brine, dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography to afford the target compound 4-chloro-6-(4-(trifluoromethyl)phenyl)pyrimidine.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 2, p. 299 - 302
[2] Patent: CN106632488, 2017, A. Location in patent: Paragraph 0167-0169
[3] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3497 - 3514
[4] Patent: US2006/241296, 2006, A1. Location in patent: Page/Page column 27
[5] Patent: WO2010/134478, 2010, A1. Location in patent: Page/Page column 165

4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidine Suppliers

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659729-09-6, 4-chloro-6-(4'-(trifluoromethyl)phenyl)pyrimidineRelated Search:

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4-Chloro-6-(4-(trifluoromethyl)

PYRIMIDINE, 4-CHLORO-6-[4-(TRIFLUOROMETHYL)PHENYL]-

659729-09-6