ChemicalBook > CAS DataBase List > N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
- Product Name
- N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
- CAS No.
- 519178-28-0
- Chemical Name
- N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine
- Synonyms
- TNP;IP6K Inhibitor;IP3K Inhibitor;TNP >=95% (HPLC);TNP, 10 mM in DMSO;IP6K1 inhibitor TNP;IP6K1 inhibitor TNP (TNP);IP6K Inhibitor - CAS 519178-28-0 - Calbiochem;N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine;N6-(4-Nitrobenzyl)-N2-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine
- CBNumber
- CB41128943
- Molecular Formula
- C20H16F3N7O2
- Formula Weight
- 443.38
- MOL File
- 519178-28-0.mol
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N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Property
- Boiling point:
- 723.4±70.0 °C(Predicted)
- Density
- 1.543±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥10mg/mL
- pka
- 10.51±0.10(Predicted)
- form
- Yellow solid
- color
- yellow
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- T3955
- Product name
- TNP
- Purity
- ≥95% (HPLC)
- Packaging
- 5mg
- Price
- $238
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- T3955
- Product name
- TNP
- Purity
- ≥95% (HPLC)
- Packaging
- 25mg
- Price
- $491.4
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- 406170
- Product name
- IP6K Inhibitor - CAS 519178-28-0 - Calbiochem
- Purity
- The IP6K Inhibitor, also referenced under CAS 519178-28-0, controls the biological activity of IP6K.
- Packaging
- 5mg
- Price
- $222
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 21189
- Product name
- TNP
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $44
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 21189
- Product name
- TNP
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $143
- Updated
- 2024/03/01
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N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Chemical Properties,Usage,Production
Uses
TNP provides a means of selectively and rapidly modulating cellular InsP7 levels in vivo without affecting levels of other inositol phosphates.
Biochem/physiol Actions
TNP is a potent and selective IP6K inhibitor; less selective inhibitor of IP3K. Discovery of TNP as an inositol trisphosphate (IP3) kinase inhibitor was first reported in 2002, However, a recent reference shows that TNP is more potent as an IP6K inhibitor, making it valuable for study of inositol pyrophosphates.
in vivo
TNP (10 mg/kg; i.p.; daily; 10 weeks) significantly reduces body weight and improves insulin resistance in male C57BL/6 mice with high-fat diet-induced obesity (DIO)[1]. TNP (20 mg/kg; i.p.; daily; 18 days) decreases fat accumulation and enhances insulin sensitivity in male C57BL/6 mice with short-term reversal of obesity[1].
storage
Store at +4°C
N6-[(4-nitrophenyl)methyl]-N2-[[3-(trifluoromethyl)phenyl]methyl]-1H-Purine-2,6-diamine Preparation Products And Raw materials
Raw materials
Preparation Products
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