4-cyano-3-methylbenzoic acid
- Product Name
- 4-cyano-3-methylbenzoic acid
- CAS No.
- 73831-13-7
- Chemical Name
- 4-cyano-3-methylbenzoic acid
- Synonyms
- 4-cyano-3-methylbenzoic acid;Benzoic acid, 4-cyano-3-methyl-;Benzoic acid, 3-methyl-4-cyano-
- CBNumber
- CB41131381
- Molecular Formula
- C9H7NO2
- Formula Weight
- 161.16
- MOL File
- 73831-13-7.mol
4-cyano-3-methylbenzoic acid Property
- Melting point:
- 216℃
- Boiling point:
- 349.1±30.0 °C(Predicted)
- Density
- 1.26
- storage temp.
- Sealed in dry,Room Temperature
- form
- Solid
- pka
- 3.61±0.10(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2926907090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C981870
- Product name
- 4-Cyano-3-methylbenzoicAcid
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- X8066
- Product name
- 4-Cyano-3-methylbenzoicacid
- Packaging
- 250mg
- Price
- $16
- Updated
- 2021/12/16
- Product number
- OR301015
- Product name
- 4-Cyano-3-methylbenzoicacid
- Packaging
- 1g
- Price
- $22
- Updated
- 2021/12/16
- Product number
- 4737-1-04
- Product name
- 4-Cyano-3-methyl-benzoic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- 075917
- Product name
- 4-Cyano-3-methylbenzoic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $116
- Updated
- 2021/12/16
4-cyano-3-methylbenzoic acid Chemical Properties,Usage,Production
Uses
4-Cyano-3-methylbenzoic Acid is used as a reactant in the preparation of 5,6-dihydrobenzo[h]quinazolin-4(3H)-ones for the inhibition of group A streptococcal streptokinase expression.
Synthesis
124-38-9
67832-11-5
73831-13-7
To a tetrahydrofuran (THF, 100 ml) solution of 4-bromo-2-methylbenzonitrile (2.0 g, 10.2 mmol) was slowly added 2.5 M n-butyllithium solution (4.48 ml, 11.2 mmol) dropwise at -78 °C and under nitrogen protection. The reaction mixture was stirred continuously at -78 °C for 1 h and subsequently poured into a tetrahydrofuran (THF, 50 ml) solution pre-loaded with solid carbon dioxide (5 g). The reaction system was slowly warmed up to room temperature. After addition of water (200 ml), extraction was carried out with ether (3 times). The aqueous layer was acidified by adding concentrated hydrochloric acid and then extracted with chloroform (3 times). The chloroform extracts were combined, washed with water, dried over anhydrous magnesium sulfate (MgSO4) and finally concentrated under vacuum to give the white solid product 4-cyano-3-methylbenzoic acid (1.2 g, 73% yield).
References
[1] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 17, p. 4585 - 4589
[2] Patent: EP1449844, 2004, A1. Location in patent: Page 21
[3] Patent: EP1512687, 2005, A1. Location in patent: Page/Page column 7
[4] Patent: WO2006/18443, 2006, A1. Location in patent: Page/Page column 21
[5] Patent: US6664249, 2003, B1. Location in patent: Page column 11
4-cyano-3-methylbenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-cyano-3-methylbenzoic acid manufacturers
- Product
- 4-cyano-3-methylbenzoic acid 73831-13-7
- Price
- US $0.00/T
- Min. Order
- 0.025T
- Purity
- 99.5%
- Supply Ability
- 2t/th
- Release date
- 2023-02-09
- Product
- 4-cyano-3-methylbenzoic acid 73831-13-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-11