ChemicalBook > CAS DataBase List > 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one

Product Name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
CAS No.
130049-82-0
Chemical Name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Synonyms
3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE;3-(2-ChL;Paliperidone-8;Paliperidone Int 1;Paliperidone USP RC C;3-(2-Chloroethyl)-6,7;Paliperidone IMpurity N;Paliperidone Impurity 55;Paliperidone Impurities105;Paliperidone Intermediate 1
CBNumber
CB41175684
Molecular Formula
C11H15ClN2O2
Formula Weight
242.7
MOL File
130049-82-0.mol
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3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Property

Melting point:
100-102°C
Boiling point:
389.3±52.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Methanol (Slightly)
form 
Solid
pka
12.97±0.60(Predicted)
color 
Pale Orange to Yellow
InChI
InChI=1S/C11H15ClN2O2/c1-7-8(4-5-12)11(16)14-6-2-3-9(15)10(14)13-7/h9,15H,2-6H2,1H3
InChIKey
JKVUGXRJSYRXFN-UHFFFAOYSA-N
SMILES
C12C(O)CCCN1C(=O)C(CCCl)=C(C)N=2
CAS DataBase Reference
130049-82-0(CAS DataBase Reference)
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Safety

HS Code 
2934990002
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C366270
Product name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Packaging
25mg
Price
$350
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20232
Product name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Packaging
100mg
Price
$380
Updated
2021/12/16
ChemScene
Product number
CS-B0009
Product name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Packaging
100g
Price
$451
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC20232
Product name
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Packaging
25mg
Price
$150
Updated
2021/12/16
AK Scientific
Product number
B784
Product name
3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
Packaging
5g
Price
$161
Updated
2021/12/16
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3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Chemical Properties,Usage,Production

Chemical Properties

Pale-Yellow Solid

Uses

Paliperidone USP Related Compound C

Synthesis

A suspension of methanol and 3-(2-Chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2a]pyrimidin-4-one Hydrochloride in a reactor was heated to 50–55 ℃ to achieve dissolution. Charcoal was then added to the solution, and heating was continued. The contents were filtered, and the charcoal cake was washed with methanol. The combined filtrate, the catalyst (10% Pd/C, 50% wet), and dichloromethane were added to a hydrogenation reactor, and the mixture was hydrogenated. The hydrogen pressure was then reduced to 28–43 psi until the completion of the reaction by HPLC. Then, the catalyst was filtered off and washed with methanol. The combined filtrate was evaporated at a temperature below 50 ℃ under reduced pressure to give a dark grayish oil (crude production 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one).

References

[1] Pavankumar V. Solanki . “Preparation of 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one, a Key Intermediate for the Synthesis of Paliperidone.” Organic Preparations and Procedures International 48 3 (2016): Pages 296-302.

3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one Suppliers

Canada 1 China 302 Germany 1 India 19 United Kingdom 2 United States 15 Global 340
SL Drugs and Pharmaceuticals Pvt. Ltd.
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View Lastest Price from 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0
Price
US $0.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-11-21
Hebei Weibang Biotechnology Co., Ltd
Product
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Hebei Mojin Biotechnology Co., Ltd
Product
3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-09-19

130049-82-0, 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-oneRelated Search:

Kresoxim-methyl 4-Ethylpyridine 1-Hydroxyethylidene-1,1-diphosphonic acid METSULFURON METHYL 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL 2-Hydroxypyridine Sulfadiazine Chromium picolinate Ethyl maltol Tribenuron methyl Thiophanate-methyl CHLOROPHOSPHONAZO III Methyl salicylate Methyl acetate Methyl 3-(2-Chloroethyl)-2-methyl-9-hydroxy-4H-pyrido[1,2-a]pyrimidin-4-one (Paliperidone) Paliperidone impurity 1 Paliperidone iMpurity I

  • 3-(2-CHLOROETHYL)-9-HYDROXY-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
  • 3-(2-Chloroethyl)-2-methyl-9-hydroxy-6,7,8,9-tetrahydro-4H-pyrido [1,2-a] pyrimidin-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-α]pyrimidin-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidine-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4h-pyrido[1,2-a]pyrimidin-4-one ,98%
  • Paliperidone Intermediate 1
  • 3-(2-chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
  • 9-tetrahydro-9-hydroxy-2-Methyl-
  • 9-Hydroxy-3-(2-chloroethyl)-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-4-one
  • 3-(2-chloroethyl)-9-hydroxy-2-Methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyriMidin-4-one
  • 4H-Pyrido[1,2-a]pyriMidin-4-one,3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-
  • 3-(2-Chloroethyl)-9-hydroxy-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • 3-(2-CHLOROEETHYL)-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDO (1,2-A) PYRIMIDIN-4-ONE
  • Paliperidone Chloro IMpurity (USP RelatedCoMpound C)
  • Paliperidone USP RC C
  • Paliperidone IMpurity N
  • Paliperidone Related CoMpound C
  • Paliperidone Int 1
  • Paliperidone Related Compound C (20 mg) (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one)
  • -(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
  • Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one)
  • 3-(2-Chloroethyl)-6,7
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-p
  • Paliperidone Impurity 9(Paliperidone USP RC C)
  • Paliperidone USP Related Compound C
  • Paliperidone-8
  • 3-(2-chloroethyl)-9-hydroxy-2-methyl-
  • )-6,7,8,9-tetrahydro-9-hydroxy-2-methyL
  • 3-(2-ChL
  • -4H-pyrido[1,2-a]pyrimidine-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrimidin-4-one
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one ISO 9001：2015 REACH
  • Paliperidone Related Compound C (Paliperidone Chloroethyl Impurity)
  • Paliperidone Impurities105
  • "3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido-[1,2-a] pyrimidine-4-one"
  • 3-(2-Chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 130049-82-0
  • Paliperidone Related Compound C (3-(2-Chloroethyl)-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[ (1491831)
  • Paliperidone Impurity 55
  • 3-(2-Chloroethy)-6,7,8,9- Tetrahydro-2-methyl-4H- pyrido-(1,2-a) pyrimidine-4- one, Hydrochloride
  • 3-(2-chloroethyl)-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-on
  • 130049-82-0
  • C11H15O2N2Cl
  • Heterocyclic Compounds
  • Bases & Related Reagents
  • Heterocycles
  • Nucleotides