Meralluride Property

Boiling point:

186°C

Safety

Toxicity

LD50 s.c. in rats: 28±7 mg/kg (Goldenthal)

Hazard and Precautionary Statements (GHS)

Meralluride Chemical Properties,Usage,Production

Originator

Mercuhydrin,Merrell National,US,1943

Manufacturing Process

First, to produce the mercury component, a pulverized mixture of 50 g of allylcarbamide and 50 g of succinic anhydride is heated for 30 minutes at 110°C. After cooling the fused mass is ground with 50 cc of cold water and the crystalline mass after quick filtering from the liquid is recrystallized from hot water. The white crystalline needles having a MP of 142° to 144°C are allyl-succinyl-carbamide. In order to produce a mercury compound thereof a mixture of 20 g of the allyl-succinyl-carbamide and 30 g of mercury acetate is shaken for 3 hours with methanol. The scarcely soluble precipitate of the mercury compound after filtration is washed with methanol and with water and dried in vacuum. The white powder melts at 185° to 186°C under decomposition. Then, condensation with an equimolar proportion of theophylline yields meralluride.

brand name

Mercuhydrin (Marion Merrell Dow).

Therapeutic Function

Diuretic