Hazard and Precautionary Statements (GHS)

Zoliprofen Chemical Properties,Usage,Production

Originator

Zoliprofen,ZYF Pharm Chemical

Manufacturing Process

A mixture of 2-chlorothiazole (5.0 g), ethyl 2-(4-hydroxyphenyl)propionate (8.1 g), potassium carbonate powder (8.65 g) and dimethylformamide (80 ml) is stirred at 150°-155°C for 2.5 hours. The solvent is distilled out under reduced pressure. To the residue is added water and extracted with ether. The extract is washed with a 10% aqueous solution of sodium hydroxide and water and dried. The ether is evaporated. The residue is subjected to chromatography using silica gel and eluted with 50% benzene-hexane, benzene and 10% ether-benzene to yield ethyl 2-[4-(2-thiazolyloxy)- phenyl]propionate (5.8 g).
The product is dissolved in a mixture of a 20% aqueous solution of potassium hydroxide (30 ml) and 95% ethanol (30 ml). The solution is kept at room temperature for 30 minutes. The solvent is evaporated. The residue is acidified with hydrochloric acid after addition of water, and extracted with ether. The extract is washed with water and dried over magnesium sulfate. The solvent is distilled out. The residue is recrystallized from ether-hexane to give 2-[4-(2-thiazolyloxy)phenyl]propionic acid (4.8 g).
The product (5.0 g) is dissolved in an aqueous solution (30 ml) of sodium hydroxide (0.82 g). To the solution washed with ether is added an aqueous solution (5 ml) of calcium chloride 2 hydrate (1.6 g) to form a precipitate. The precipitate washed with water gives calcium 2-[4-(2-thiazolyloxy)phenyl]propionate (5.5 g) melting at 143°-145°C.

Therapeutic Function

Antiinflammatory, Analgesic