Zopolrestat

Product Name: Zopolrestat
CAS No.: 110703-94-1
Chemical Name: Zopolrestat
Synonyms: Xedia;Alond;CP-73850;Zopalrestat;Zopolrestatum;Zopolrestat, CP-73850;Zopolrestat >=98% (HPLC);BCSVCWVQNOXFGL-UHFFFAOYSA-N;3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid;3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid
CBNumber: CB41180112
Molecular Formula: C19H12F3N3O3S
Formula Weight: 419.38
MOL File: 110703-94-1.mol

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Zopolrestat Property

Melting point:: 197-198℃
Density: 1.58
storage temp.: 2-8°C
solubility: DMSO: ≥20mg/mL
pka: pKa (dioxane/water): 5.46 (1:1); 6.38 (2:1)
form: powder
color: off-white to light brown

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Z4527
Product name: Zopolrestat
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $122
Updated: 2024/03/01

Sigma-Aldrich

Product number: Z4527
Product name: Zopolrestat
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $475
Updated: 2024/03/01

Cayman Chemical

Product number: 29185
Product name: Zopolrestat
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 29185
Product name: Zopolrestat
Packaging: 5mg
Price: $116
Updated: 2024/03/01

Cayman Chemical

Product number: 29185
Product name: Zopolrestat
Packaging: 10mg
Price: $214
Updated: 2024/03/01

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Zopolrestat Chemical Properties,Usage,Production

Originator

Alond,Pfizer

Uses

Antidiabetic; inhibitor (aldose reductase).

Manufacturing Process

A mixture of 2-methyl-5-trifluoromethylbenzothiazole (1 mole-equivalent), N- bromosuccinimide (1 mole-equivalent), carbon tetrachloride (700 ml) and a catalytic amount of benzoyl peroxide (0.2 g) was refluxed under irradiation by an UV lamp for 14 hours. The reaction mixture was cooled to room temperature, filtered to remove the precipitated succinimide and the filtrate was evaporated to dryness. The resulting solid was chromatographed over silica gel to obtain the 2-bromomethyl-5-trifluoromethyl-benzothiazole. To a mixture of ethyl 4-oxo-3H-phthalazin-1-ylacetate (1 mole-equivalent) and sodium hydride (50% w/w dispersion in mineral oil) in dimethylformamide (150 ml) was added 2-bromomethyl-5-trifluoromethylbenzothiazole (1 mole- equivalent) and the resulting mixture stirred at room temperature for 1 hour. This reaction mixture was poured over ice-water (500 ml); sufficient 10% HCl was added to adjust the pH to about 4.0 and the precipitated crude solid was collected. This was chromatographed over silica gel to obtain the ethyl[4-oxo- 3-(5-trifluoromethylbenzothiazol-2-yl)-3,4-dihydro-phthalazin-1-yl]acetate; MP: 134°-136°C. A solution of methyl or ethyl [4-oxo-3-(5-trifluoromethylbenzothiazol-2-yl)- 3,4-dihydrophthalazin-1-yl]acetate (1 mole-equivalent) in methanol (50 ml)

Therapeutic Function

Aldose reductase inhibitor

Zopolrestat Preparation Products And Raw materials

Raw materials

Preparation Products

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Zopolrestat Suppliers

China 16 Switzerland 1 United Kingdom 1 United States 6 Global 24

Sinopharm Chemical Reagent Co,Ltd.

Tel: 86-21-63210123
Fax: 86-21-63290778 86-21-63218885
Email: sj_scrc@sinopharm.com
Country: China
ProdList: 9823
Advantage: 79

Shanghai Hekang Biotechnology Co., Ltd.

Tel: 18939837085
Fax: 2880152141(QQ)
Email: youchemicals@gmail.com
Country: China
ProdList: 1813
Advantage: 55

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Alfa Chemistry

Tel: +1-5166625404
Fax: 1-516-927-0118
Email: Info@alfa-chemistry.com
Country: United States
ProdList: 21317
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19553
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49390
Advantage: 58

Energy Chemical

Tel: 021-58432009 400-005-6266
Fax: 021-58436166
Email: marketing1@energy-chemical.com
Country: China
ProdList: 44894
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 15221909166
Email: product02@bidepharm.com
Country: China
ProdList: 61720
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6712
Advantage: 58

110703-94-1, ZopolrestatRelated Search:

BENZOTHIAZOL-2-YLMETHYL-METHYL-AMINE 1,3-BENZOTHIAZOL-2-YLMETHYLAMINE HYDROCHLORIDE N-Methylthiazole-2-methanamine 1-((benzo[d]thiazol-2-yl)methyl)hydrazine BENZYL-THIAZOL-2-YLMETHYL-AMINE (4-OXO-3,4-DIHYDROPHTHALAZIN-1-YL)ACETIC ACID (3-METHYL-4-OXO-3,4-DIHYDRO-PHTHALAZIN-1-YL)-ACETIC ACID Zopolrestat (2-Thiazolyl)methylamine 2-METHYL-5-(TRIFLUOROMETHYL)BENZOTHIAZOLE 5-TRIFLUOROMETHYLBENZOTHIAZOLE

3-[(5-Trifluoromethyl-2-benzothiazolyl)methyl]-3,4-dihydro-4-oxophthalazine-1-acetic acid

CP-73850

Zopalrestat

Zopolrestat, CP-73850

3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1-phthalazineacetic acid

Alond

Xedia

BCSVCWVQNOXFGL-UHFFFAOYSA-N

1-Phthalazineacetic acid, 3,4-dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-

Zopolrestat >=98% (HPLC)

Zopolrestatum

diabetic,potent,glyceraldehyde,glucose,aldose,rats,inhibit,Aldose Reductase,Zopolrestat,Inhibitor,oral

2-(4-Oxo-3-((5-(trifluoromethyl)benzo[d]thiazol-2-yl)methyl)-3,4-dihydrophthalazin-1-yl)acetic acid

110703-94-1