N-METHYLBARBITURIC ACID

Product Name: N-METHYLBARBITURIC ACID
CAS No.: 2565-47-1
Chemical Name: N-METHYLBARBITURIC ACID
Synonyms: 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione;1-methylbarbituric acid;Alogliptin-17;N-Methylbarituric Acid;alogliptina impurity 5;alogliptin impurities2;N-METHYLBARBITURIC ACID;3-METHYLBARBITURIC ACID;N-Methylbarituric Acid 1;alogliptin impurities149
CBNumber: CB4119977
Molecular Formula: C5H6N2O3
Formula Weight: 142.11
MOL File: 2565-47-1.mol

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N-METHYLBARBITURIC ACID Property

Melting point:: 132 °C
Density: 1.379±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Sparingly), Methanol (Slightly)
form: Solid
pka: pK1:4.35(＋1) (25°C)
color: White to Off-White
InChI: InChI=1S/C5H6N2O3/c1-7-4(9)2-3(8)6-5(7)10/h2H2,1H3,(H,6,8,10)
InChIKey: DCGGMHIZEAHUJL-UHFFFAOYSA-N
SMILES: C1(=O)N(C)C(=O)CC(=O)N1

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M294025
Product name: 1-MethylbarbituricAcid
Packaging: 500mg
Price: $100
Updated: 2021/12/16

Usbiological

Product number: 410072
Product name: 1-Methylbarbituric Acid
Packaging: 1mg
Price: $496
Updated: 2021/12/16

AK Scientific

Product number: 2116AB
Product name: 1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione
Packaging: 1g
Price: $239
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010740
Product name: N-METHYLBARBITURIC ACID
Purity: 95.00%
Packaging: 1MG
Price: $597.89
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0010740
Product name: N-METHYLBARBITURIC ACID
Purity: 95.00%
Packaging: 10MG
Price: $631.85
Updated: 2021/12/16

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N-METHYLBARBITURIC ACID Chemical Properties,Usage,Production

Uses

1-Methylbarbituric Acid is an impurity of Trelagliptin. Trelagliptin (Zafatek) is a pharmaceutical drug used for the treatment of type 2 diabetes.

Synthesis

141-82-2

598-50-5

2565-47-1

Acetic anhydride (130 mL, 1.37 mol) was slowly added dropwise to 180 mL of acetic acid solution containing malonic acid (80 g, 0.79 mol) and N-methylurea (50 g, 0.68 mol) at 70 °C. After the dropwise addition was completed, the reaction mixture was warmed up to 90 °C with continuous stirring for 3 hours. After completion of the reaction, the mixture was cooled to room temperature. The solvent was removed by distillation under reduced pressure and the resulting residue was treated with 350 mL of ethanol to precipitate a pale yellow solid. The solid was purified by recrystallization from ethanol to give 63.1 g of 1-methylpyrimidine-2,4,6(1H,3H,5H)-trione as a final crystalline solid (yield: 65.8%). The melting point was measured to be 131.2-133.1 °C (literature value: 130-131.5 °C).

References

[1] Journal of Heterocyclic Chemistry, 2014, vol. 51, # 3, p. 594 - 597
[2] Journal of Medicinal Chemistry, 1989, vol. 32, # 6, p. 1231 - 1237
[3] Patent: WO2009/73210, 2009, A1. Location in patent: Page/Page column 76
[4] Patent: WO2006/133261, 2006, A2. Location in patent: Page/Page column 30
[5] Patent: WO2007/143705, 2007, A2. Location in patent: Page/Page column 23

N-METHYLBARBITURIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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N-METHYLBARBITURIC ACID Suppliers

China 87 Germany 1 India 4 South Korea 1 Switzerland 1 United Kingdom 1 United States 7 Global 102

Nanjing Chalf-Pharm Technology Co., Ltd.

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Energy Chemical

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Fax: 025-87193546
Email: chemweiao@163.com
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BOC Sciences

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Shanghai Hekang Biotechnology Co., Ltd.

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Bide Pharmatech Ltd.

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Synchem OHG

Tel: +49 5662 408730
Fax: +49 5662 4087320
Email: info@synchem.de
Country: Germany
ProdList: 4705
Advantage: 70

ChemStrong Scientific Co.,Ltd

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Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 18333
Advantage: 56

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View Lastest Price from N-METHYLBARBITURIC ACID manufacturers

Career Henan Chemical Co

Product: N-METHYLBARBITURIC ACID 2565-47-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98% HPCL
Supply Ability: 10t
Release date: 2019-12-20

2565-47-1, N-METHYLBARBITURIC ACIDRelated Search:

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N-METHYLBARBITURIC ACID

1-methylbarbituric acid

1-Methyl-2,4,6-Trihydroxy-Pyrimidine

1-Methylpyrimidine-2,4,6(1H,3H,5H)-trione

3-METHYLBARBITURIC ACID

Alogliptin-17

N-Methylbarituric Acid 1

1-methyl-1,3-diazinane-2,4,6-trione

1-Methylpyrimidine-2,4,6(1H,3H,5H)

N-Methylbarituric Acid

2,4,6(1H,3H,5H)-Pyrimidinetrione,1-methyl-

1-Methyl-pyrimidine-2,4,6-trione

alogliptina impurity 5

alogliptin impurities149

alogliptin impurities2

(R)-tert-butyl (1-(3-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-cyanophenyl)piperidin-3-yl)carbamate

2565-47-1