ChemicalBook > CAS DataBase List > Ascorbyl Palmitate

Ascorbyl Palmitate

Product Name
Ascorbyl Palmitate
CAS No.
137-66-6
Chemical Name
Ascorbyl Palmitate
Synonyms
ASCORBIC ACID 6-PALMITATE;Vitamin C Palmitate;Palmitoyl ascorbate;L-ASCORBYL PALMITATE;PALMITOYL L-ASCORBIC ACID;E304;scorbic;ascorbyl;Ascorbate palmitate;L-ASCORBYL 6-PALMITATE
CBNumber
CB4121121
Molecular Formula
C22H38O7
Formula Weight
414.53
MOL File
137-66-6.mol
More
Less

Ascorbyl Palmitate Property

Melting point:
115-118 °C(lit.)
alpha 
+21～+26°(20℃/D, c=2, C2H5OH)
Boiling point:
512.7±50.0 °C(Predicted)
Density 
1.150±0.06 g/cm3(Predicted)
refractive index 
22.5 ° (C=1, EtOH)
storage temp. 
2-8°C
solubility 
Slightly soluble in ethyl alcohol.
form 
Solid
pka
3.96±0.10(Predicted)
color 
White to Pale Gray
Odor
wh. or yel.-wh. powd., citrus odor
optical activity
[α]20/D +23±1°, c = 1% in ethanol
BRN 
96552
InChIKey
QAQJMLQRFWZOBN-UWJYYQICSA-N
LogP
6.5 at 30℃ and pH1.9
CAS DataBase Reference
137-66-6(CAS DataBase Reference)
EPA Substance Registry System
Ascorbyl palmitate (137-66-6)
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-36-24/25
WGK Germany 
1
RTECS 
CI7671040
TSCA 
Yes
HS Code 
2936 27 00
Hazardous Substances Data
137-66-6(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: > 5000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
76183
Product name
6-O-Palmitoyl-L-ascorbic acid
Purity
BioXtra, ≥99.0% (RT)
Packaging
25g
Price
$64.5
Updated
2024/03/01
Sigma-Aldrich
Product number
5.00090
Product name
L(+)Ascorbyl palmitate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,NF,FCC,E 304
Packaging
2.5kg
Price
$1367
Updated
2024/03/01
Sigma-Aldrich
Product number
5.00090
Product name
L(+)Ascorbyl palmitate
Purity
EMPROVE? ESSENTIAL Ph Eur,BP,NF,FCC,E 304
Packaging
10Kg
Price
$3964
Updated
2024/03/01
Sigma-Aldrich
Product number
1043105
Product name
Ascorbyl Palmitate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
500mg
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
02134
Product name
6-O-Palmitoyl-L-ascorbic acid
Purity
analytical standard
Packaging
500MG
Price
$70
Updated
2022/05/15
More
Less

Ascorbyl Palmitate Chemical Properties,Usage,Production

Description

Ascorbyl palmitate is a lipophilic derivative of ascorbic acid with antioxidant and antiproliferative activities. It scavenges hydroxyl radicals in cell-free assays. Ascorbyl palmitate (0.01%) reduces the rate of autoxidation of soybean, safflower, sunflower, peanut, and corn oil. It inhibits increases in epidermal ornithine decarboxylase activity and DNA synthesis induced by phorbol 12-myristate 13-acetate (TPA; ) in mice in a concentration-dependent manner when applied topically. Ascorbyl palmitate (0.8 and 4 μmol per 200 μl of acetone, applied topically) reduces the number of tumors per mouse and the percentage of mice with tumors in a mouse skin two-stage model of tumor formation initiated and promoted by 7,12-dimethylbenz[a]anthracene (DMBA) and TPA, respectively. Formulations containing ascorbyl palmitate have been used as antioxidants and preservatives in foods, pharmaceuticals, and cosmetics.

Chemical Properties

Ascorbyl palmitate is a white or yellowish-white solid with a soapy taste and a citrus-like odor. It is very slightly soluble in water but freely soluble in alcohol, animal oil, and vegetable oil. It melts at 107° to 117°C (around 234°F). Ascorbyl palmitate prevents oxidative rancidity development by quenching singlet oxygen. The ascorbic acid part of the molecule donates hydrogen (a reducing agent). This phenomenon is also called "oxygen scavenging".

Uses

Ascorbyl Palmitate is an ester formed from ascorbic acid and palmitic acid creating a fat soluble form of vitamin C. It is used as an antioxidant food additive. It is also used as a preservative and an anti-oxidant in cosmetic creams and lotions to prevent rancidity. Ascorbyl palmitate facilitates the incorporation of ingredients such as vitamins A, C, and D into cosmetic formulations. It has no known toxicity.

Definition

ChEBI: Ascorbyl palmitate is a fatty acid ester. It is derived from corn dextrose fermentation and palm oil. It is used as a food preservative and as an antioxidant in oils, fats, and pharmaceuticals.

Production Methods

Ascorbyl palmitate is prepared synthetically by the reaction of ascorbic acid with sulfuric acid followed by reesterification with palmitic acid.

Application

Ascorbyl Palmitate is an antioxidant formed by combining ascorbic acid with palmitic acid. ascorbic acid is not fat soluble but ascorbyl palmitate is, thus combining them produces a fat-soluble antioxidant. it exists as a white or yellowish white powder of citric- like odor. it is used as a preservative for natural oils, edible oils, colors, and other substances. it acts synergistically with alpha-tocopherol in oils/fats. it is used in peanut oil at a maximum level of 200 mg/kg individually or in combination.

General Description

A white or yellowish-white powder having a citrus-like odor. Mp 116–117°C; soluble in alcohol and in animal and vegetable oils; slightly soluble in water. Ascorbyl Palmitate is a lipophilic ascorbic acid derivative, used as an antioxidant in both food and cosmetics industries.

Pharmaceutical Applications

Ascorbyl palmitate is primarily used either alone or in combination with alpha tocopherol as a stabilizer for oils in oral pharmaceutical formulations and food products; generally 0.05% w/v is used. It may also be used in oral and topical preparations as an antioxidant for drugs unstable to oxygen. The combination of ascorbyl palmitate with alpha tocopherol shows marked synergism, which increases the effect of the components and allows the amount used to be reduced.
The solubility of ascorbyl palmitate in alcohol permits it to be used in nonaqueous and aqueous systems and emulsions.

Biochem/physiol Actions

6-O-Palmitoyl-L-ascorbic acid possesses metastasis inhibitory and anti-tumor activity. Ascorbyl palmitate exhibits antioxidant activity by protecting the cell membranes from oxidative damage.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Ascorbyl palmitate is used in oral pharmaceutical formulations and food products, and is generally regarded as an essentially nontoxic and nonirritant material. The WHO has set an estimated acceptable daily intake for ascorbyl palmitate at up to 1.25 mg/kg bodyweight.
LD50 (mouse, oral): 25 g/kg
LD50 (rat, oral): 10 g/kg

storage

Ascorbyl palmitate is stable in the dry state, but is gradually oxidized and becomes discolored when exposed to light and high humidity. In an unopened container, stored in a cool place, it has a shelf life of at least 12 months. During processing, temperatures greater than 658℃ should be avoided.
The bulk material should be stored in an airtight container at 8–158℃, protected from light.

Incompatibilities

Incompatibilities are known with oxidizing agents; e.g. in solution oxidation is catalyzed by trace metal ions such as Cu2+ and Fe3+.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral, rectal, topical preparations). Included in nonparenteral medicines licensed in the UK.

Ascorbyl Palmitate Preparation Products And Raw materials

Raw materials

Ascorbic Acid Porcelain ring packing Thionyl chloride Palmitic acid Palmitoyl chloride

Preparation Products

More
Less

Ascorbyl Palmitate Suppliers

Americas 1 Australia 1 Austria 1 Belgium 1 Brazil 1 Canada 2 China 468 Denmark 1 Europe 5 France 3 Germany 13 India 51 Japan 4 Poland 1 Singapore 1 South Korea 2 Spain 2 Switzerland 5 The Netherlands 2 United Kingdom 10 United States 67 USA 1 Global 643
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
Advantage
70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Alfa Chemistry
Tel
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
24072
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
TargetMol Chemicals Inc.
Tel
+8613564774135
Email
zijue.cai@tsbiochem.com
Country
United States
ProdList
19885
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Cayman Chemical Company
Tel
--
Fax
--
Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
Selleck Chemicals LLC
Tel
--
Fax
--
Email
sales@selleckchem.com
Country
United States
ProdList
1848
Advantage
58
Charles Bowman & Company
Tel
--
Fax
--
Country
United States
ProdList
37
Advantage
58
Bell Chem Corp.
Tel
--
Fax
--
Email
uiry@bellchem.com
Country
United States
ProdList
174
Advantage
58
DSM Nutritional Products
Tel
--
Fax
--
Email
info@dsm.com
Country
United States
ProdList
30
Advantage
58
Cosmetic Supplies Usa Inc
Tel
--
Fax
--
Email
info@cosmeticsuppliesusa.com
Country
United States
ProdList
15
Advantage
58
NutriPharm USA, Inc.
Tel
--
Fax
--
Email
nutripharmusa@gmail.com
Country
United States
ProdList
31
Advantage
58
Alpha Environmental
Tel
--
Fax
--
Email
info@alpha-environmental.com
Country
United States
ProdList
8
Advantage
58
Asiamerica Ingredients, Inc.
Tel
--
Fax
--
Email
info@asiamericaingredients.com
Country
United States
ProdList
99
Advantage
0
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
United States Biological
Tel
--
Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80
ECSA Chemicals
Tel
--
Fax
--
Email
marketing@ecsa.ch
Country
United States
ProdList
1735
Advantage
58
American International Chemical, Inc.
Tel
--
Fax
--
Email
info@aicma.com
Country
United States
ProdList
531
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
Jiangyin Healthway International Trade Co., Ltd
Tel
--
Fax
--
Email
info@healthwaychem.com
Country
United States
ProdList
1006
Advantage
58
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
Bosgen Chemical Inc.
Tel
--
Fax
--
Email
sale@chemapi.com
Country
United States
ProdList
609
Advantage
30
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
235
Advantage
68
Hawkins, Inc.
Tel
--
Fax
--
Email
ir@hawkinsinc.com
Country
United States
ProdList
212
Advantage
30
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Aceto Corporation
Tel
--
Fax
--
Email
contact@aceto.com
Country
United States
ProdList
2619
Advantage
75
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Wintersun Chemical
Tel
--
Fax
--
Email
purchasing@wintersunchem.com
Country
United States
ProdList
776
Advantage
68
More
Less

View Lastest Price from Ascorbyl Palmitate manufacturers

HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
Ascorbyl Palmitate 137-66-6
Price
US $500.00-300.00/ton
Min. Order
1ton
Purity
99%
Supply Ability
5000
Release date
2024-08-23
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Ascorbic acid 6-palmitate 137-66-6
Price
US $60.00/kg
Min. Order
1kg
Purity
99
Supply Ability
5000
Release date
2024-05-08
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Ascorbyl Palmitate 137-66-6
Price
US $20.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000kg/Week
Release date
2024-05-06

137-66-6, Ascorbyl PalmitateRelated Search:

L-Ascorbic acid 6-stearate Tocopheryl acetate DL-METHIONINE METHYLSULFONIUM CHLORIDE D-Biotin Vitamin K1 Vitamin D3 Menadione sodium bisulfite TOCOPHEROL L-Lysine-L-aspartate 2,6-DIISOCYANATOHEXANOIC ACID 2-ISOCYANATOETHYL ESTER L-Arginine ethyl ester dihydrochloride Calcium ascorbate dihydrate Magnesium ascorbyl phosphate Vitamin D2 Sodium ascorbate Pyridoxine Pyridoxine hydrochloride Ascorbic Acid

  • PALMITOYL L-ASCORBIC ACID
  • 6-O-Palmitoyl ascorbate
  • Palmitoyl ascorbate
  • Ascorbyl Palmitate (2 g)
  • Ascorbyl Palmitate (2 g) (AS)
  • ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(P)
  • Ascorbyl palMitate / 6-PalMitoylascorbic acid
  • VitaMin C Oil Soluble /L-Ascorbyl PalMitate
  • ASCORBIC ACID PALMITATE
  • ASCORBIC ACID 6-PALMITATE
  • ASCORBYL PALMITATE
  • L-ASCORBYL 6-PALMITATE
  • L(+)ASCORBYL PALMITATE
  • L-ASCORBYL PALMITATE
  • L-ASCORBIC ACID PALMITATE
  • L-ASCORBIC ACID, 6-HEXADECANOATE
  • L-ASCORBIC ACID 6-PALMITATE
  • (S)-2-((R)-3,4-Dihydroxy-5-oxo-2,5-dihydrofuran-2-yl)-2-hydroxyethyl palMitate
  • ASCORBYL PALMITATE(RG)
  • Ascorbyl palMitate USP
  • Ascorbyl palMi
  • E304
  • NSC 402451
  • Ascorbyl Palmitate (500 mg)
  • 6-O-Palmitoyl-L-ascorbic acid Vetec(TM) reagent grade, 95%
  • ASCORBIC ACID 6-PALMITATE, VETEC
  • 6-hexadecanoyl-l-ascorbicacid
  • 6-monopalmitoyl-l-ascorbate
  • 6-o-palmitoylascorbicacid
  • ascorbicacidpalmitate(ester)
  • ascorbicpalmitate
  • ascorbyl
  • ascorbylmonopalmitate
  • ascorbylpalmiticacid
  • cetylascorbate
  • l-ascorbylmonopalmitate
  • ondascora
  • quicifal
  • scorbic
  • scorbicpalmitate
  • LGB-AP
  • [2-(4,5-DIHYDROXY-3-OXO-2-FURYL)-2-HYDROXY-ETHYL] HEXADECANOATE
  • 6-O-HEXADECANOYL-L-ASCORBIC ACID
  • 6-PALMITOYLASCORBIC ACID
  • 6-O-PALMITOYL-L-ASCORBIC ACID
  • Ascorbylpalmitate,95%
  • Vitamin C Palmitate
  • Ascorbyl palmitate FCCIV
  • L-ascoryl palitate
  • Ascorbyl palmitate BP/USP/FCC
  • L-ASCORBIC ACID 6-PALMITATE USP
  • (S)-2-[(R)-3,4-dihydroxy-5-oxo-2,5-dihydro-2-furyl]-2-hydroxyethyl hexadecanoate
  • ASCORBYLPALMITATE,FCC
  • Ascorbyl Palmitate(BP/EP/USP/FCC)
  • ASCORBYL PALMITATE(ASCORBIC ACID-6-PALMITATE)(SH)
  • ASCORBYL PALMITATE(USP)(RG)
  • 6-0-PALMITOYL-L-ASCORBICACID
  • 6-O-Palmitoylascorbinsure