4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride

Product Name: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
CAS No.: 284490-13-7
Chemical Name: 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
Synonyms: BCX-1777;Forodesine HCl;Fodosine Hydrochloride;BCX-1777 hydrochloride;Forodesine hydrochloride;Immucillin-H hydrochloride;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride
CBNumber: CB41211465
Molecular Formula: C11H15ClN4O4
Formula Weight: 302.72
MOL File: 284490-13-7.mol

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4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride Property

Melting point:: 268-270°C
storage temp.: Hygroscopic, Refrigerator, under inert atmosphere
solubility: DMSO (Slightly), Water (Slightly)
form: Solid
color: Off-White to Pale Beige
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3378
Product name: Forodesine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5MG
Price: $95.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3378
Product name: Forodesine hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25MG
Price: $385
Updated: 2024/03/01

ChemScene

Product number: CS-3780
Product name: Forodesine(hydrochloride)
Purity: 99.86%
Packaging: 5mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-3780
Product name: Forodesine(hydrochloride)
Purity: 99.86%
Packaging: 10mg
Price: $1080
Updated: 2021/12/16

ChemScene

Product number: CS-3780
Product name: Forodesine(hydrochloride)
Purity: 99.86%
Packaging: 1mg
Price: $216
Updated: 2021/12/16

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4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride Chemical Properties,Usage,Production

Uses

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma.

Uses

Fodosine Hydrochloride is a 23-pM inhibitor of bovine purine nucleoside phosphorylase (PNP) specifically designed as a transition state mimic.

Biological Activity

Forodesine (BCX-1777; ImmH; Immucillin-H) is an orally active, tight-binding (bovine/human PNP Ki = 23/72 pM) and highly potent purine nucleoside phosphorylase (PNP, PNPase) inhibtor (IC50 in nM = 0.48/mouse, 0.66/monkey, 1.19/human, 1.24/rat, 1.57/dog) th at mimics the PNP transition-state structure. Forodesine inhibits human T-cell proliferation stimulated by IL-2, MLR- and PHA in cultures (IC50 in the presence of 10 μM dGuo = 60, 50, and 387 nM, respectively) and shows in vivo efficacy in a xenogeneic graft vs. host disease model using hu-PBL SCID mice (20 mg/kg b.i.d. p.o.).

4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride Suppliers

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284490-13-7, 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochlorideRelated Search:

4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-, monohydrochloride

Forodesine hydrochloride

BCX-1777

Immucillin-H hydrochloride

Forodesine HCl

BCX-1777 hydrochloride

Fodosine Hydrochloride

284490-13-7