ASPERPHENAMATE

Product Name: ASPERPHENAMATE
CAS No.: 63631-36-7
Chemical Name: ASPERPHENAMATE
Synonyms: Auranamide;ASPERPHENAMATE;Asperphenamate, 10 mM in DMSO;N-Benzoyl-L-phenylalanine (S)-2-benzoylamino-3-phenylpropyl ester;(2S)-2-(Benzoylamino)-3-phenylpropanoic acid (2S)-2-(benzoylamino)-3-phenylpropyl ester
CBNumber: CB41245088
Formula Weight: 0
MOL File: 63631-36-7.mol

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ASPERPHENAMATE Property

storage temp.: Store at -20°C
solubility: DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
form: A solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25086
Product name: Asperphenamate
Purity: ≥95%
Packaging: 1mg
Price: $305
Updated: 2024/03/01

Cayman Chemical

Product number: 25086
Product name: Asperphenamate
Purity: ≥95%
Packaging: 5mg
Price: $1139
Updated: 2024/03/01

ChemScene

Product number: CS-0106762
Product name: Asperphenamate
Purity: ≥98.0%
Packaging: 5mg
Price: $580
Updated: 2021/12/16

ChemScene

Product number: CS-0106762
Product name: Asperphenamate
Purity: ≥98.0%
Packaging: 10mg
Price: $800
Updated: 2021/12/16

Adipogen Life Sciences

Product number: AG-CN2-0171-C250
Product name: Asperphenamate
Purity: ≥95%(HPLC)
Packaging: 250μg
Price: $90
Updated: 2021/12/16

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ASPERPHENAMATE Chemical Properties,Usage,Production

Description

Asperphenamate is a fungal secondary metabolite originally isolated from A. flavipes. It inhibits proliferation of T47D and MDA-MB-231 breast and HL-60 leukemia cancer cell lines (IC₅₀s = 92.3, 96.5, and 97.9 μM, respectively) and inhibits yeast α-glucosidase activity (IC₅₀ = 8.3 μM).

Uses

Asperphenamate is an α-glucosidase inhibitor isolated from Penicillium spathulatum. Asperphenamate exhibits anticancer properties and is used to synthesize N-Benzoyl-O-(N''-(1-benzyloxycarbonyl-4-piperidiylcarbonyl)-D-phenylalanyl)-D-phenylalaninol (BBP), an asperphenamate derivative that inhibits human breast carcinoma MCF-7 cell growth.

Definition

ChEBI: Asperphenamate is a carboxylic ester resulting from the formal condensation of the carboxy group of N-benzoyl-L-phenylalanine with the hydroxy group of N-benzoyl-L-phenylalaninol. A metabolite found in several Pencillium and Aspergillus species, as well as in plants as a product of endophytic fungi. It has a role as an antineoplastic agent. It is a L-phenylalanine derivative, a member of benzamides and a carboxylic ester. It is functionally related to a N-benzoyl-L-phenylalanine and a N-benzoyl-L-phenylalaninol.

References

[1] ALICE M. CLARK Charles D H. Synthesis of asperphenamate, a novel fungal metabolite[J]. Phytochemistry, 1978, 17 3: Pages 552-553. DOI: 10.1016/s0031-9422(00)89363-2
[2] LEI YUAN Tie M S Jin Hui Wang. Total synthesis and anticancer activity studies of the stereoisomers of asperphenamate and patriscabratine[J]. Chinese Chemical Letters, 2010, 21 2: Pages 155-158. DOI: 10.1016/j.cclet.2009.10.004
[3] PAULINA DEL VALLE. Alkaloids from the Fungus Penicillium spathulatum as α-Glucosidase Inhibitors.[J]. Planta medica, 2016, 82 14: 1286-1294. DOI: 10.1055/s-0042-111393

ASPERPHENAMATE Preparation Products And Raw materials

Raw materials

Preparation Products

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ASPERPHENAMATE Suppliers

China 27 United States 7 Global 34

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Beijing Jin Ming Biotechnology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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TargetMol Chemicals Inc.

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Hangzhou Huarong Pharm Co., Ltd.

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BOC Sciences

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Meng Cheng Technology (Shanghai) Co., LTD

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Beijing Jin Ming Biotechnology Co., Ltd.

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TargetMol Chemicals Inc.

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Shanghai Yiyan Biotechnology Co. , Ltd.

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63631-36-7, ASPERPHENAMATERelated Search:

ASPERPHENAMATE

(2S)-2-(Benzoylamino)-3-phenylpropanoic acid (2S)-2-(benzoylamino)-3-phenylpropyl ester

Auranamide

N-Benzoyl-L-phenylalanine (S)-2-benzoylamino-3-phenylpropyl ester

Asperphenamate, 10 mM in DMSO

63631-36-7