ChemicalBook > CAS DataBase List > Ethanone, 2-chloro-1-(3-indolyl)-
Ethanone, 2-chloro-1-(3-indolyl)-
- Product Name
- Ethanone, 2-chloro-1-(3-indolyl)-
- CAS No.
- 28755-03-5
- Chemical Name
- Ethanone, 2-chloro-1-(3-indolyl)-
- Synonyms
- 3CAI;3CAI >=95% (HPLC);3-chloroacetylindole;Akt Inhibitor XIX, 3CAI;Chloromethyl indol-3-yl ketone;3-(Chloroacetyl)-1H-indole 95%;2-Chloro-1-(3-Indolyl)-Ethanone;Ethanone, 2-chloro-1-(3-indolyl)-;Ethanone, 2-chloro-1H-indol-1-yl-;Ethanone, 2-chloro-1-(1H-indol-3-yl)-
- CBNumber
- CB41247653
- Molecular Formula
- C10H8ClNO
- Formula Weight
- 193.63
- MOL File
- 28755-03-5.mol
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Ethanone, 2-chloro-1-(3-indolyl)- Property
- Melting point:
- 212-214 °C(Solv: ethyl ether (60-29-7))
- Boiling point:
- 379.1±17.0 °C(Predicted)
- Density
- 1.337±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: soluble5mg/mL, clear
- form
- powder
- pka
- 15.08±0.30(Predicted)
- color
- yellow to brown
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 124037
- Product name
- Akt Inhibitor XIX, 3CAI
- Packaging
- 25mg
- Price
- $195
- Updated
- 2023/01/07
Cayman Chemical
- Product number
- 14303
- Product name
- 3CAI
- Purity
- ≥95%
- Packaging
- 250mg
- Price
- $93
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14303
- Product name
- 3CAI
- Purity
- ≥95%
- Packaging
- 500mg
- Price
- $166
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 14303
- Product name
- 3CAI
- Purity
- ≥95%
- Packaging
- 1g
- Price
- $275
- Updated
- 2024/03/01
TRC
- Product number
- C382623
- Product name
- 3-(Chloroacetyl)indole
- Packaging
- 1g
- Price
- $290
- Updated
- 2021/12/16
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Ethanone, 2-chloro-1-(3-indolyl)- Chemical Properties,Usage,Production
Uses
3-(Chloroacetyl)indole is a reagent used in organic synthesis. Used in the preparation of 1,?2-?dihydroazepino[4,?5-?b]?indoles.
Biological Activity
3cai is a potent allosteric and specific inhibitor of akt, which directly binds with akt1 or akt2 in an atp noncompetitive manner and shows 60% inhibition of akt1 kinase activity at 1 μm [1]. the serine/threonine kinase akt includes three members, akt1, akt2, and akt3. akt plays a critical role in promoting transformation and chemoresistance through inducing proliferation and inhibiting apoptosis. therefore, akt is regarded as a potential target for cancer therapy.
in vitro
3cai (1 and 4 μm) significantly inhibited akt1 kinase activity and decreased expression of akt direct downstream targets including mtor and gsk3β, respectively. 3cai (4 μm) efficiently induced growth inhibition and apoptosis in hct116 or hct29 colon cancer cells [1].
in vivo
3cai (30 mg/kg, oral administration) significantly suppressed colon cancer growth in an in vivo xenograft mouse model and inhibited the expression of akt-target protein such as mtor and gsk3βin hct116 colon tumor tissues [1].
target
akt
IC 50
1 μm
References
1. kim dj, reddy k, kim mo, li y, nadas j, cho yy, et al. (3-chloroacetyl)-indole, a novel allosteric akt inhibitor, suppresses colon cancer growth in vitro and in vivo. cancer prev res (phila). 2011;4(11):1842-51.
Ethanone, 2-chloro-1-(3-indolyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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