N-Pyrazinylthiourea
- Product Name
- N-Pyrazinylthiourea
- CAS No.
- 31437-05-5
- Chemical Name
- N-Pyrazinylthiourea
- Synonyms
- -Pyrazinylthiourea;N-Pyrazinylthiourea;Thiourea, N-2-pyrazinyl-;1-(Pyrazin-2-Yl)Thiourea
- CBNumber
- CB41249622
- Molecular Formula
- C5H6N4S
- Formula Weight
- 154.19
- MOL File
- 31437-05-5.mol
N-Pyrazinylthiourea Property
- Melting point:
- 128 °C
- Boiling point:
- 311.6±45.0 °C(Predicted)
- Density
- 1.482±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 11.25±0.70(Predicted)
- Appearance
- Light yellow to brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- P993623
- Product name
- pyrazin-2-ylthiourea
- Packaging
- 50mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0036399
- Product name
- 1-(Pyrazin-2-yl)thiourea
- Packaging
- 1g
- Price
- $178
- Updated
- 2021/12/16
- Product number
- CS-0036399
- Product name
- 1-(Pyrazin-2-yl)thiourea
- Packaging
- 5g
- Price
- $442
- Updated
- 2021/12/16
- Product number
- 4628AQ
- Product name
- pyrazin-2-ylthiourea
- Packaging
- 5g
- Price
- $442.4
- Updated
- 2021/12/16
- Product number
- CHM0311213
- Product name
- (PYRAZIN-2-YL)THIOUREA
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $505.58
- Updated
- 2021/12/16
N-Pyrazinylthiourea Chemical Properties,Usage,Production
Synthesis
31437-04-4
31437-05-5
Ammonium thiocyanate (17.8 g, 0.234 mol) was dissolved in anhydrous acetone (200 mL) under nitrogen protection and cooled to 0°C. Benzoyl chloride (30 g, 0.213 mol) was slowly added dropwise over 15 min, keeping the reaction temperature at 0 °C. After the dropwise addition was completed, the reaction mixture was warmed to room temperature and stirring was continued for 30 min, followed by filtration. To the filtrate, 2-aminopyrazine (16.2 g, 0.17 mol) was added and the reaction was stirred at room temperature for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was diluted with water to precipitate a solid. The solid was collected by filtration and dried to give N-[(pyrazin-2-ylamino)thiocarbonyl]benzamide (33 g, 76% yield).TLC conditions: chloroform/methanol (9:1), Rf=0.5.N-[(pyrazin-2-ylamino)thiocarbonyl]benzamide (25 g, 0.096 mol) was dissolved in 10% NaOH solution (200 mL) and stirred at 80°C for 20 min. and stirred at 80 °C for 20 min. The reaction mixture was cooled and the solvent was removed under reduced pressure. The residue was acidified to pH=1 with 2 M HCl and subsequently alkalized with ammonium hydroxide. The precipitated solid was collected by filtration and dried by suction to give 1-(pyrazin-2-yl)thiourea (12 g, 80% yield). Product characterization: 1H NMR (DMSO-d6, 300 MHz): δ 8.24 (br s, 2H), 8.54 (s, 1H), 9.10 (m, 1H), 9.95 (m, 1H), 10.66 (br s, 1H). Mass Spectrometry (ESI): m/z 154.9 [M+H]+. HPLC (Method B): retention time 3.47 min (purity 98.23%). TLC: Chloroform/methanol (9:1), Rf=0.25. Melting point: 234-235°C.
References
[1] Patent: WO2006/125805, 2006, A1. Location in patent: Page/Page column 50-51
[2] Bioorganic and Medicinal Chemistry Letters, 2003, vol. 13, # 16, p. 2641 - 2645
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 12, p. 3081 - 3085
[4] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3706 - 3712
[5] Tetrahedron Letters, 2018, vol. 59, # 17, p. 1623 - 1626
N-Pyrazinylthiourea Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from N-Pyrazinylthiourea manufacturers
- Product
- N-Pyrazinylthiourea 31437-05-5
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-07-20
- Product
- N-Pyrazinylthiourea 31437-05-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98
- Supply Ability
- 200kg
- Release date
- 2019-09-10