Suzetrigine

Product Name: Suzetrigine
CAS No.: 2649467-58-1
Chemical Name: Suzetrigine
Synonyms: VX-548;suzetrigin;Suzetrigine;Suzetrigine1;FANDACHEM VX-548;SUZETRIGINE/VAX548;VX-548（Suzetrigine）;Suzetrigine (VX-548);FANDACHEM Suzetrigine;Suzetrigine，PhEur/USP(DMF)
CBNumber: CB412520545
Molecular Formula: C21H20F5N3O4
Formula Weight: 473.4
MOL File: 2649467-58-1.mol

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Suzetrigine Property

Boiling point:: 591.8±50.0 °C(Predicted)
Density: 1.399±0.06 g/cm3(Predicted)
solubility: Acetonitrile: Slightly Soluble: 0.1-1 mg/ml
DMSO: Sparingly Soluble: 1-10 mg/ml
form: Solid
pka: 11.74±0.70(Predicted)
color: White to light yellow
InChIKey: XSQUJFKRXZMOKA-KRZZIQMTNA-N
SMILES: C([C@@H]1O[C@@](C)(C(F)(F)F)[C@@H](C)[C@H]1C1C=CC(F)=C(F)C=1OC)(=O)NC1=CC=NC(C(=O)N)=C1 |&1:1,3,9,11,r|

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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Suzetrigine Chemical Properties,Usage,Production

Description

Suzetrigine is an inhibitor of voltage-gated sodium channel 1.8 (Nav1.8; IC50 = 0.7 nM for the human channel).1 It is selective for Nav1.8 over a panel of eight additional voltage-gated sodium channels (IC50s = >10,000 nM for all).WARNING This product is not for human or veterinary use.

Synthesis

The synthesis of Suzetrigine (VX-548) revolves around the highly stereoselective construction of its tetrahydropyran core. A typical synthetic route begins with a chiral starting material (e.g., a chiral epoxide) that undergoes a stereoselective addition reaction with a fluoroaryllithium reagent, introducing a phenyl group and a trifluoromethyl group. Subsequently, a nucleophilic cyclization reaction forms the crucial tetrahydropyran ring, thus determining the correct configuration of the four stereocenters. Subsequent steps involve standard organotransformation reactions, such as cross-coupling reactions (e.g., the Suzuki coupling reaction), to introduce the pyridine moiety, ultimately yielding the final Suzetrigine product via deprotection and salt formation.

References

[1] JIM JONES. Selective Inhibition of NaV1.8 with VX-548 for Acute Pain.[J]. New England Journal of Medicine, 2023, 389 5: 393-405. DOI: 10.1056/nejmoa2209870

Suzetrigine Preparation Products And Raw materials

Raw materials

Preparation Products

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Suzetrigine Suppliers

China 152 India 2 United States 2 Global 156

Hangzhou Chemtrue Bio-Tech Co.,Ltd.

Tel: 0571-86828652 18857119830
Fax: 0571-83522824
Email: sales@chemtrue-bio.com
Country: China
ProdList: 258
Advantage: 58

Tianjin Maitian Technology Co., Ltd

Tel: 19102267946
Email: motitech@126.com
Country: China
ProdList: 134
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9858
Advantage: 58

Chengdu Yunyidian Biological Technology Co.,Ltd

Tel: 17621298782
Email: sales@cdyunyidian.com
Country: China
ProdList: 258
Advantage: 58

Taizhou Nanfeng Pharmaceutical Research Institute

Tel: nanfengpharma@126.co 18616377689
Email: nanfengpharma@126.com
Country: China
ProdList: 20009
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 492
Advantage: 55

Beijing Hope International Pharmaceutical Technology Development Co., Ltd

Tel: 01067886402 15600038801
Fax: 010-67887110-8016
Email: wuhangjin@hopelife.cn
Country: China
ProdList: 20
Advantage: 58

Chengdu Miracle Pharmaceutical Co., Ltd.

Tel: 028-86136736 19130631884
Fax: 028-85265615
Email: sales@mic-pharma.com
Country: China
ProdList: 343
Advantage: 56

Jinan Hongda Trading Co., Ltd.

Tel: 13292149980 13292149980
Email: Yaffi26@163.com
Country: China
ProdList: 151
Advantage: 58

Cangzhou Kangrui Medical Technology Co., LTD

Tel: 18632776803
Email: cangzhoukangrui@126.com;355803330@qq.com
Country: China
ProdList: 640
Advantage: 58

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View Lastest Price from Suzetrigine manufacturers

Rongchuang International

Product: Suzetrigine 2649467-58-1
Price: US $0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 9999
Release date: 2026-03-02

.GZ HONESTCHEM CO.,LTD

Product: SUZETRIGINE 2649467-58-1
Price: US $1.00/g
Min. Order: 300g
Purity: 99.8%
Supply Ability: 20 TONS
Release date: 2025-11-01

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Suzetrigine 2649467-58-1
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2025-09-10

2649467-58-1, SuzetrigineRelated Search:

2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-

VX-548

Suzetrigine

VX-548（Suzetrigine）

Suzetrigine (VX-548)

(2S,3S,4S,5R)-N-(2-((aminooxy)carbonyl)pyridin-4-yl)-3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamide

4-[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carboxamido]picolinamide

(2R,3S,4S,5R)-4-[[3-(3,4-difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)tetrahydrofuran-2-carbonyl]amino]pyridine-2-carboxamide

SUZETRIGINE/VAX548

FANDACHEM VX-548

FANDACHEM Suzetrigine

VX-548/Suzetrigine FANDACHEM

Suzetrigine / VX-548 FANDACHEM

VX-548/Suzetrigine MANUFACTURER FANDACHEM

Buy VX-548/Suzetrigine from FANDACHEM

VX-548/Suzetrigine FOR SALE

PURCHASE VX-548/Suzetrigine

VX-548/Suzetrigine DISTRIBUTOR

VX-548/Suzetrigine PRICE COST

suzetrigin

"2-Pyridinecarboxamide, 4-[[[(2R,3S,4S,5R)-3-(3,4 -difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]ami"

Suzetrigine，PhEur/USP(DMF)

Suzetrigine1

4-[[[(2R,3S,4S,5R)-3-(3,4-Difluoro-2-methoxyphenyl)-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-pyridinecarboxamide

4-[[[(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl)tetrahydro-4,5-dimethyl-5-(trifluoromethyl)-2-furanyl]carbonyl]amino]-2-Pyridinecarboxamide

2649467-58-1

SUZETRIGINE

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