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3-amino-5-methyl-1H-pyrazole-4-carbonitrile

Product Name
3-amino-5-methyl-1H-pyrazole-4-carbonitrile
CAS No.
5453-07-6
Chemical Name
3-amino-5-methyl-1H-pyrazole-4-carbonitrile
Synonyms
NSC 19055;5-Amino-4-cyano-3-methylpyrazole;5-Amino-4-cyano-3-methyl-1H-pyrazole;3-Amino-5-methylpyrazole-4-carbonitrile;5-Amino-3-methylpyrazole-4-carbonitrile;3-amino-5-methyl-1H-pyrazole-4-carbonitrile;3-azanyl-5-methyl-1H-pyrazole-4-carbonitrile;1H-Pyrazole-4-carbonitrile, 3-amino-5-methyl-
CBNumber
CB41257449
Molecular Formula
C5H6N4
Formula Weight
122.13
MOL File
5453-07-6.mol
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3-amino-5-methyl-1H-pyrazole-4-carbonitrile Property

Melting point:
162℃
Boiling point:
429.4±45.0 °C(Predicted)
Density 
1.32
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
solid
pka
12.14±0.50(Predicted)
color 
Brown
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Safety

HS Code 
2933199090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

TRC
Product number
A614683
Product name
5-Amino-3-methyl-1H-pyrazole-4-carbonitrile
Packaging
50mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
125965
Product name
3-Amino-5-methyl-1H-pyrazole-4-carbonitrile
Purity
>95%
Packaging
1g
Price
$253
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA134677
Product name
5-Amino-3-methyl-1H-pyrazole-4-carbonitrile
Packaging
1g
Price
$255
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA134677
Product name
5-Amino-3-methyl-1H-pyrazole-4-carbonitrile
Packaging
2g
Price
$434
Updated
2021/12/16
AK Scientific
Product number
V6532
Product name
3-Amino-4-cyano-5-methylpyrazole
Packaging
5g
Price
$434
Updated
2021/12/16
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3-amino-5-methyl-1H-pyrazole-4-carbonitrile Chemical Properties,Usage,Production

Synthesis

5417-82-3

5453-07-6

General procedure for the synthesis of 3-amino-5-methyl-1H-pyrazole-4-carbonitrile from 2-(1-ethoxyethylidene)malononitrile: Hydrazine hydrate (4.5 mL, 92 mmol) was added to a 50 mL round-bottomed flask and stirred at room temperature. Subsequently, 2-(1-ethoxyethylidene)malononitrile (5.0 g, 37 mmol) was added in batches. When half of the ingredients were added, the flask was transferred to an ice water bath to continue the reaction. Upon completion of the addition, a precipitate was observed to form, at which point the reaction flask was removed from the ice-water bath and heated to reflux for 2 hours, after which it was cooled to room temperature. The reaction mixture was briefly cooled in an ice water bath and subsequently sonicated to promote crystallization. The solid product was collected by filtration, washed with water and dried under vacuum to give the final 3-amino-5-methyl-1H-pyrazole-4-carbonitrile (2.69 g, 60% yield).1H NMR (300 MHz, d6-DMSO) δ 3.31 (s, 3H).

References

[1] Patent: WO2018/89786, 2018, A1. Location in patent: Paragraph 00148
[2] Patent: US2012/202785, 2012, A1. Location in patent: Page/Page column 259
[3] Journal of Organic Chemistry, 1956, vol. 21, p. 1240,1242
[4] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 8, p. 821 - 826
[5] Patent: US2006/135526, 2006, A1. Location in patent: Page/Page column 21

3-amino-5-methyl-1H-pyrazole-4-carbonitrile Preparation Products And Raw materials

Raw materials

Preparation Products

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3-amino-5-methyl-1H-pyrazole-4-carbonitrile Suppliers

China 50 India 4 Japan 1 United Kingdom 2 United States 10 Global 67
Shanghai YuYuan Pharmaceutical Co., Ltd.
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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025-66113011 17798518460
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(1)02557626880
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SynAsst Chemical.
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Bide Pharmatech Ltd.
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400-164-7117 13681763483
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+86-21-61629029
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
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Wuhan Chemwish Technology Co.， Ltd
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027-67849912
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Shanghai EFE Biological Technology Co., Ltd.
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5453-07-6, 3-amino-5-methyl-1H-pyrazole-4-carbonitrileRelated Search:

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