ChemicalBook > CAS DataBase List > Ravuconazole

Ravuconazole

Product Name
Ravuconazole
CAS No.
182760-06-1
Chemical Name
Ravuconazole
Synonyms
Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Rafconazole;Ravuconazole;Levaconazole
CBNumber
CB41257944
Molecular Formula
C22H17F2N5OS
Formula Weight
437.47
MOL File
182760-06-1.mol
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Ravuconazole Property

Melting point:
64-66°C
alpha 
D24 -29.1° (c = 1.03 in methanol)
Boiling point:
674.9±65.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form 
A crystalline solid
pka
11.62±0.29(Predicted)
color 
Off-white to yellow
optical activity
[α]/D -27 to -33°, c =1 in methanol
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1216
Product name
Ravuconazole
Purity
≥97% (NMR)
Packaging
5mg
Price
$132
Updated
2024/03/01
Sigma-Aldrich
Product number
SML1216
Product name
Ravuconazole
Purity
≥97% (NMR)
Packaging
25MG
Price
$520
Updated
2024/03/01
Cayman Chemical
Product number
18750
Product name
Ravuconazole
Purity
≥98%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18750
Product name
Ravuconazole
Purity
≥98%
Packaging
5mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
18750
Product name
Ravuconazole
Purity
≥98%
Packaging
10mg
Price
$193
Updated
2024/03/01
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Ravuconazole Chemical Properties,Usage,Production

Description

Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.

Chemical Properties

Off-White Solid

Uses

Ergosterol biosynthesis inhibitor. Antifungal.

Definition

ChEBI: Ravuconazole is a member of the class of triazoles that is 1-butyl-1H-1,2,4-triazole in which the butyl group is substituted at positions 2, 2, and 3 by hydroxy, 2,4-difluorophenyl, and 4-(p-cyanophenyl)-1,3-thiazol-2-yl groups, respectively (the R,R stereoisomer). It exhibits antifungal activity by inhibition of 14alpha demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCIO4) It has a role as an ergosterol biosynthesis inhibitor, an antifungal drug, an EC 1.14.14.154 (sterol 14alpha-demethylase) inhibitor and an antileishmanial agent. It is a member of triazoles, a member of fluorobenzenes, a tertiary alcohol, a member of 1,3-thiazoles and a nitrile.

Ravuconazole Preparation Products And Raw materials

Raw materials

Preparation Products

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Ravuconazole Suppliers

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View Lastest Price from Ravuconazole manufacturers

Qiuxian Baitai New Material Co., LTD
Product
4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
Price
US $110.00/KG
Min. Order
100g
Purity
99.99%
Supply Ability
5ton/Month
Release date
2021-11-26
Career Henan Chemical Co
Product
4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile 182760-06-1
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

182760-06-1, RavuconazoleRelated Search:

Voriconazole Fosfluconazole

  • Aids057176
  • 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
  • [R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile
  • Aids-057176
  • Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
  • Bms-207,147
  • Bms-207147
  • Er-30346
  • Rcz
  • Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
  • Ravuconazole, BMS-207147
  • BMS-207147/Ravuconazole
  • 4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
  • The health
  • Ravuconazole
  • inhibit,ER30346,BMS207147,Ravuconazole,BMS 207147,Fungal,ER 30346,Inhibitor
  • Levaconazole
  • Rafconazole
  • Ravuconazole Impurity 1
  • Ravuconazole, 10 mM in DMSO
  • 182760-06-1
  • C22H17F2N5OS
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals