ChemicalBook > CAS DataBase List > (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid

(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid

Product Name
(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid
CAS No.
128253-31-6
Chemical Name
(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid
Synonyms
VELIFLAPON;DG 031;BAY 1005;Velifapon;BAY-X 1005;BAY-X-1005 >=98% (HPLC);ZEYYDOLCHFETHQ-JOCHJYFZSA-N;2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid;α-Cyclopentyl-4-(2-quinolinylmethoxy)-(R)-benzeneacetic acid;(αR)-α-Cyclopentyl-4-(2-quinolinylmethoxy)-benzeneacetic acid
CBNumber
CB41260812
Molecular Formula
C23H23NO3
Formula Weight
361.43
MOL File
128253-31-6.mol
More
Less

(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid Property

Melting point:
169-171 °C
Boiling point:
555.4±40.0 °C(Predicted)
Density 
1.242±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: soluble5mg/mL (clear solution)
form 
powder
pka
4.47±0.10(Predicted)
color 
white to beige
More
Less

Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0411
Product name
BAY-X-1005
Purity
≥98% (HPLC)
Packaging
5mg
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0411
Product name
BAY-X-1005
Purity
≥98% (HPLC)
Packaging
25mg
Price
$631
Updated
2024/03/01
Tocris
Product number
3541
Product name
BAY-X1005
Purity
≥98%(HPLC)
Packaging
1
Price
$113
Updated
2021/12/16
TRC
Product number
B127620
Product name
BAY-X1005
Packaging
1mg
Price
$115
Updated
2021/12/16
TRC
Product number
B127620
Product name
BAY-X1005
Packaging
2.5mg
Price
$250
Updated
2021/12/16
More
Less

(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid Chemical Properties,Usage,Production

Uses

Prevention of acute cardiovascular events.

Biological Activity

bay-x 1005 is a selective inhibitor of 5-lipoxygenase-activating protein [1].5-lipoxygenase-activating protein (flap) is an integral protein and plays an important role in the activation of 5-lipoxygenase (5-lox) and the synthesis of leukotrienes, which regulating immune responses.bay-x 1005 is a selective inhibitor of leukotriene synthesis. bay x 1005 binds to flap and inhibits 5-lox translocation from the cytosol to membranes [1]. bay-x1005 inhibited ltb4 synthesis with ic50 values of 0.22, 0.026 and 0.039 μm for isolated pmnl of human, rat and mouse respectively and inhibited ltc4 synthesis with ic50 value of 0.021 μm in mouse macrophages [2].in the arachidonate-induced mouse ear inflammation test, bay-x 1005 inhibited myeloperoxidase activity and edema formation with ed50 values of 7.9 and 48.7, respectively [2].also, bay-x 1005 (100 mg/kg) reduced platelet-activating factor-induced death of mice by 51% in a dose-dependent way. in animal models, bay-x 1005 inhibited the synthesis of ltb4 and ltc4, which reduced edema formation, the vascular phenomena of inflammation and leukocyte immigration [3].

References

[1]. hatzelmann a, fruchtmann r, mohrs kh, et al. mode of action of the leukotriene synthesis (flap) inhibitor bay x 1005: implications for biological regulation of 5-lipoxygenase. agents actions, 1994, 43(1-2): 64-68.
[2]. müller-peddinghaus r, fruchtmann r, ahr hj, et al. bay x1005, a new selective inhibitor of leukotriene synthesis: pharmacology and pharmacokinetics. j lipid mediat, 1993, 6(1-3): 245-248.
[3]. müller-peddinghaus r, kohlsdorfer c, theisen-popp p, et al. bay x1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. j pharmacol exp ther, 1993, 267(1): 51-57.

(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid Suppliers

LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2127
Advantage
70
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
19892
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing1@energy-chemical.com
Country
China
ProdList
44843
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
cjbscvictory
Tel
13348960310 13348960310
Email
3003867561@qq.com
Country
China
ProdList
10011
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24017
Advantage
58
Suzhou Zhixin Biotechnology Co., Ltd.
Tel
0512-65118909 15162312715
Email
sales@szzxbio.com
Country
China
ProdList
2992
Advantage
58
Nantong QuanYi Biotechnology Co., Ltd
Tel
0513-66337626 18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
4299
Advantage
58

128253-31-6, (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acidRelated Search:


  • (2R)-2-cyclopentyl-2-[4-(quinolin-2-ylmethoxy)phenyl]acetic acid
  • 2-(4-(quinolin-2-yl-methoxy)phenyl)-2-cyclopentylacetic acid
  • VELIFLAPON
  • BAY-X 1005
  • BAY 1005
  • DG 031
  • Velifapon
  • (αR)-α-Cyclopentyl-4-(2-quinolinylmethoxy)-benzeneacetic acid
  • α-Cyclopentyl-4-(2-quinolinylmethoxy)-(R)-benzeneacetic acid
  • ZEYYDOLCHFETHQ-JOCHJYFZSA-N
  • Benzeneacetic acid, α-cyclopentyl-4-(2-quinolinylmethoxy)-, (αR)-
  • BAY-X-1005 >=98% (HPLC)
  • 128253-31-6