ChemicalBook > CAS DataBase List > (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one

(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one

Product Name
(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
CAS No.
667-66-3
Chemical Name
(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
Synonyms
B-Cortolone;2-Cortolone;β-Cortolone;β-Cortolone D5;5β-pregnan-3α, 17, 20β, 21-tetrol-11-one;5β-PREGNAN-3α, 17, 20β, 21-TETROL-11-ONE;(20R)-3α,17α,20,21-Tetrahydroxy-5β-pregnan-11-one;Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-;(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
CBNumber
CB41260847
Molecular Formula
C21H34O5
Formula Weight
366.495
MOL File
667-66-3.mol
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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Property

Melting point:
249-258oC
Boiling point:
564.1±50.0 °C(Predicted)
Density 
1.248±0.06 g/cm3(Predicted)
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly, Heated), Methanol (Slightly, Heated), Pyridine (Slightly)
pka
13.95±0.70(Predicted)
form 
Solid
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TRC
Product number
C696285
Product name
β-Cortolone
Packaging
50mg
Price
$595
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
63783
Product name
β-Cortolone
Packaging
10mg
Price
$490
Updated
2021/12/16
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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Chemical Properties,Usage,Production

Uses

β-Cortolone is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.

Definition

ChEBI: Beta-Cortolone is a 21-hydroxy steroid.

(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Preparation Products And Raw materials

Raw materials

Preparation Products

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(3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one Suppliers

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667-66-3, (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-oneRelated Search:

5B-PREGNANE-3A-17A-20B-TRIOL*CRYSTALLINE 5BETA-PREGNAN-3ALPHA, 17ALPHA, 20BETA, 21-TETROL-11-ONE-3BETA-D-GLUCURONIDE-20 21-ACETONIDE (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one 2-HEPTANONE，5-(HYDROXYMETHYL) Menthone 5-BETA-PREGNAN-3-ALPHA, 20-BETA-DIOL

  • (3R,5R,8S,9S,10S,13S,14S,17R)-17-[(1R)-1,2-dihydroxyethyl]-3,17-dihydr oxy-10,13-dimethyl-2,3,4,5,6,7,8,9,12,14,15,16-dodecahydro-1H-cyclopen ta[a]phenanthren-11-one
  • B-Cortolone
  • (20R)-3α,17α,20,21-Tetrahydroxy-5β-pregnan-11-one
  • 2-Cortolone
  • 5β-pregnan-3α, 17, 20β, 21-tetrol-11-one
  • β-Cortolone
  • β-Cortolone D5
  • Pregnan-11-one, 3,17,20,21-tetrahydroxy-, (3α,5β,20R)-
  • 5β-PREGNAN-3α, 17, 20β, 21-TETROL-11-ONE
  • 667-66-3