4,5,6,7-tetrahydro-1H-benzoimidazole
- Product Name
- 4,5,6,7-tetrahydro-1H-benzoimidazole
- CAS No.
- 3752-24-7
- Chemical Name
- 4,5,6,7-tetrahydro-1H-benzoimidazole
- Synonyms
- 4,5,6,7-Tetrahydrobenzimidazole;4,5,6,7-TETRAHYDRO-1H-BENZIMIDAZOLE;1H-Benzimidazole, 4,5,6,7-tetrahydro-
- CBNumber
- CB41261208
- Molecular Formula
- C7H10N2
- Formula Weight
- 122.17
- MOL File
- 3752-24-7.mol
4,5,6,7-tetrahydro-1H-benzoimidazole Property
- Melting point:
- 150 °C
- Boiling point:
- 335.0±11.0 °C(Predicted)
- Density
- 1.133±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 15.15±0.20(Predicted)
- Appearance
- White to off-white Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T889538
- Product name
- 4,5-Tetramethyleneimidazole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- OR912584
- Product name
- 4,5,6,7-Tetrahydro-1H-benzoimidazole
- Purity
- 95%
- Packaging
- 1g
- Price
- $31
- Updated
- 2021/12/16
- Product number
- OR912584
- Product name
- 4,5,6,7-Tetrahydro-1H-benzoimidazole
- Purity
- 95%
- Packaging
- 5g
- Price
- $132
- Updated
- 2021/12/16
- Product number
- 119096
- Product name
- 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $238
- Updated
- 2021/12/16
- Product number
- 119096
- Product name
- 4,5,6,7-Tetrahydro-1H-benzo[d]imidazole
- Purity
- 95+%
- Packaging
- 1g
- Price
- $594
- Updated
- 2021/12/16
4,5,6,7-tetrahydro-1H-benzoimidazole Chemical Properties,Usage,Production
Uses
4,5-Tetramethyleneimidazole is a useful reactant for preparation of imidazolylnitroquinoxalinedione.
Synthesis Reference(s)
The Journal of Organic Chemistry, 41, p. 19, 1976 DOI: 10.1021/jo00863a004
Synthesis
51-17-2
3752-24-7
The general procedure for the synthesis of 4,5,6,7-tetrahydro-1H-benzimidazole from benzimidazole was as follows: a suspension of benzimidazole (3.0 g, 25.4 mmol) with Pd/C (Degussa 5 wt%; 1.3 g) in acetic acid (50 mL) was added to a Parr reactor, and the reaction was carried out at 80 °C and 200 psi hydrogen pressure overnight. Upon completion of the reaction, the mixture was cooled to room temperature, filtered through diatomaceous earth and the diatomaceous earth pad was washed several times with distilled water. The filtrates were combined and the pH was adjusted to 9 with solid K2CO3, followed by liquid-liquid separation by addition of ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 4,5,6,7-tetrahydro-1H-benzimidazole (2.4 g, 77% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 1.82-1.85 (m, 4H), 2.06-2.10 (m, 4H), 7.55 (s, 1H), 10.21 (br s, NH).LC-MS (ES+) analysis showed m/z 123 ([M+H]+) and retention time (RT) was consistent with the solvent front (method A).
References
[1] Organic Letters, 2004, vol. 6, # 5, p. 735 - 738
[2] Patent: WO2015/86513, 2015, A1. Location in patent: Page/Page column 87; 88
[3] Patent: US2018/186773, 2018, A1. Location in patent: Paragraph 0793; 0794; 0795
[4] Journal fuer Praktische Chemie (Leipzig), 1958, vol. <4> 7, p. 207,212
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View Lastest Price from 4,5,6,7-tetrahydro-1H-benzoimidazole manufacturers
- Product
- 4,5,6,7-tetrahydro-1H-benzoimidazole 3752-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20t
- Release date
- 2024-07-14
- Product
- 4,5,6,7-tetrahydro-1H-benzoimidazole 3752-24-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2020-01-09
- Product
- 4,5,6,7-tetrahydro-1h-benzimidazole 3752-24-7
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- 95%min
- Supply Ability
- 20kgs/month
- Release date
- 2019-11-13