6-Methylbenzo[b]thiophene-2-carboxylic acid
- Product Name
- 6-Methylbenzo[b]thiophene-2-carboxylic acid
- CAS No.
- 1467-86-3
- Chemical Name
- 6-Methylbenzo[b]thiophene-2-carboxylic acid
- Synonyms
- benzo[b]thiophene-2-carboxyL;6-Methylbenzo[b]thiophene-2-carboxylic;6-Methylbenzothiophene-2-carboxylic acid;6-Methylbenzo[b]thiophene-2-carboxylic acid;6-Methyl-1-benzothiophene-2-carboxylic acid;6-Methylbenzo[b]thiophene-2-carboxylicacid99%;Benzo[b]thiophene-2-carboxylic acid, 6-methyl-;6-Methylbenzo[b]thiophene-2-carboxylic acid 99%;6-Methyl-1-benzothiophene-2-carboxylic acid, 2-Carboxy-6-methyl-1-benzothiophene
- CBNumber
- CB41263222
- Molecular Formula
- C10H8O2S
- Formula Weight
- 192.23
- MOL File
- 1467-86-3.mol
6-Methylbenzo[b]thiophene-2-carboxylic acid Property
- Melting point:
- 243-244°C
- Boiling point:
- 386.1±22.0 °C(Predicted)
- Density
- 1.355±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- Powder
- pka
- 3.56±0.30(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C10H8O2S/c1-6-2-3-7-5-9(10(11)12)13-8(7)4-6/h2-5H,1H3,(H,11,12)
- InChIKey
- KQRBOHOKLNORTA-UHFFFAOYSA-N
- SMILES
- C12=CC(C)=CC=C1C=C(C(O)=O)S2
Safety
- Hazard Codes
- Xi
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- OR3103
- Product name
- 6-Methylbenzo[b]thiophene-2-carboxylicacid
- Purity
- 99%
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- 6H21-1-X7
- Product name
- 6-Methylbenzo[b]thiophene-2-carboxylic acid
- Purity
- 99%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- 3047AL
- Product name
- 6-Methylbenzo[b]thiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- OR3103
- Product name
- 6-Methylbenzo[b]thiophene-2-carboxylicacid
- Purity
- 99%
- Packaging
- 10g
- Price
- $496
- Updated
- 2021/12/16
- Product number
- 188189
- Product name
- 6-Methylbenzo[b]thiophene-2-carboxylic acid
- Packaging
- 5g
- Price
- $526
- Updated
- 2021/12/16
6-Methylbenzo[b]thiophene-2-carboxylic acid Chemical Properties,Usage,Production
Synthesis
34576-96-0
7440-44-0
1467-86-3
Example 17 Synthesis of 6-methylbenzo[b]thiophene-2-carboxylic acid (1) (Method C) (MeOH/water and ammonium formate) Procedure: a suspension of palladium in 5% wet charcoal (50% water, 1.065 g) and ammonium formate (2.52 g) in methanol (30 ml) was stirred for 20 minutes under inert atmosphere. Subsequently, a solution consisting of 2.52 g of ammonium formate in 5 ml of water and a solution consisting of 2.26 g of 3-chloro-6-methylbenzo[b]thiophene-2-carboxylic acid (18), 70 ml of methanol and 10 ml of 1N NaOH were added. The reaction mixture was stirred at reflux for 15 hours under inert atmosphere. After that, 0.425 g of Pd/C (5% wet) was added and the reaction mixture was continued to reflux for 24 hours. Upon completion of the reaction, the mixture was cooled, diluted with methanol, filtered through a bed of diatomaceous earth and the catalyst was further washed. The filtrate was evaporated to dryness under reduced pressure and the residue was treated with 70 ml of 1N HCl and 250 ml of ethyl acetate. The organic phase was washed three times with brine and evaporated to dryness to give 1.82 g of the target compound (1) as a white solid; the HPLC purity was 98.2% and the yield was 94.7%.
References
[1] Patent: US2012/65370, 2012, A1
6-Methylbenzo[b]thiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Methylbenzo[b]thiophene-2-carboxylic acid manufacturers
- Product
- 6-Methylbenzo[b]thiophene-2-carboxylic acid 1467-86-3
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 100 tons
- Release date
- 2022-01-26
- Product
- 6-Methylbenzo[b]thiophene-2-carboxylic acid 1467-86-3
- Price
- US $5.50/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 1kg,10kg100kg
- Release date
- 2020-01-09