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3-Pyridinecarboxamide,2-methyl-(9CI)

Product Name
3-Pyridinecarboxamide,2-methyl-(9CI)
CAS No.
58539-65-4
Chemical Name
3-Pyridinecarboxamide,2-methyl-(9CI)
Synonyms
2-methylnicotinamide;Olutasidenib Impurity 33;2-Methyl-3-PyridinecarboxaMide;3-Pyridinecarboxamide, 2-methyl-;2-Methylnicotinamide, 97%, QA-0097;3-Pyridinecarboxamide,2-methyl-(9CI);2-Methylnicotinamide (~12% inorganics);3-Pyridinecarboxamide,2-methyl-(9CI) ISO 9001：2015 REACH
CBNumber
CB41274929
Molecular Formula
C7H8N2O
Formula Weight
136.15
MOL File
58539-65-4.mol
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3-Pyridinecarboxamide,2-methyl-(9CI) Property

Melting point:
158 °C
Boiling point:
271.9±28.0 °C(Predicted)
Density 
1.157±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
14.85±0.50(Predicted)
color 
White to Off-White
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Safety

HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

SynQuest Laboratories
Product number
4H48-1-63
Product name
2-Methylnicotinamide
Purity
97%
Packaging
1g
Price
$152
Updated
2021/12/16
Matrix Scientific
Product number
074646
Product name
2-Methylnicotinamide
Purity
95%
Packaging
25g
Price
$225
Updated
2021/12/16
AK Scientific
Product number
W7162
Product name
2-Methylnicotinamide
Packaging
25g
Price
$353
Updated
2021/12/16
Matrix Scientific
Product number
074646
Product name
2-Methylnicotinamide
Purity
95%
Packaging
5g
Price
$74
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0167328
Product name
2-METHYLNICOTINAMIDE
Purity
95.00%
Packaging
1G
Price
$704.55
Updated
2021/12/16
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3-Pyridinecarboxamide,2-methyl-(9CI) Chemical Properties,Usage,Production

Chemical Properties

White solid

Uses

2-Methylnicotinamide (~12% inorganics) can be used as JAK inhibitors to treat autoimmune disease or cancer.

Definition

ChEBI: 2-methylnicotinamide is a pyridinecarboxamide that is nicotinamide substituted by a methyl group at C-2. It has a role as a metabolite. It is functionally related to a nicotinamide.

Synthesis

3222-56-8

58539-65-4

General procedure for the synthesis of 2-methylnicotinamide from 2-methylnicotinic acid: 2-methylnicotinic acid (0.537 mg, 3.9 mmol) was dissolved in 20 mL of DMF at 0 °C, and HATU (1.56 g, 4.1 mmol) and DIPEA (0.72 mL, 4.1 mmol) were added sequentially. Subsequently, ammonia (NH3) was passed into the reaction system for 15 min. The reaction mixture was stirred overnight at room temperature. After completion of the reaction, the paste was obtained by filtration, washed with cold DMF and the filtrate was discarded. The mother liquor was concentrated and purified by normal phase chromatography with the eluent being MeOH solution of CH2Cl2/7N NH3 (93:7, v/v). The final white solid product 2-methylnicotinamide (405 mg, 76% yield) was obtained. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 1.34 (s, 9H), 1.36 (d, J = 6.64 Hz, 3H), 2.56 (s, 3H), 4.32-4.40 (m, 1H), 7.15-7.19 (m, J = 8.20 Hz, 1H), 7.68 (d, J = 8.20 Hz, 1H) .

References

[1] Patent: WO2007/73303, 2007, A2. Location in patent: Page/Page column 38
[2] Patent: EP1193265, 2002, A2. Location in patent: Page 76-77
[3] Patent: US2013/281397, 2013, A1. Location in patent: Paragraph 0438; 0439
[4] Journal of Medicinal Chemistry, 2000, vol. 43, # 16, p. 3168 - 3185
[5] European Journal of Medicinal Chemistry, 2012, vol. 55, p. 58 - 66,9

3-Pyridinecarboxamide,2-methyl-(9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Pyridinecarboxamide,2-methyl-(9CI) Suppliers

China 106 Europe 1 India 2 United Kingdom 2 United States 7 Global 118
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
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60
Shangchem Co., Ltd.
Tel
+86-21-68182121
Fax
+86-21-68182121
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China
ProdList
882
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52
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9883
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Shanghai Ennopharm Co., Ltd.
Tel
+86 (21) 6435-5022
Country
China
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4267
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skychemical Co.Ltd
Tel
021-20958197 20965099
Fax
021-20960837
Email
sales@skychemical.com
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China
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1183
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Hunan Hui Bai Shi Biotechnology Co., Ltd.
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0731-85526065 13308475853
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ivy@hnhbsj.com
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China
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7247
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Hangzhou Yuhao Chemical Technology Co., Ltd
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0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
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China
ProdList
6387
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Chengdu Forest Science and Technology Development Co., Ltd.
Tel
18030648795
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028-61777050
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sales@cdforestchem.com
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China
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2000
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Shanghai Topbiochem Technology Co., Ltd
Tel
+86-21-60341587
Fax
+86-21-61294319
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sales@topbiochem.com
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China
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6175
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Nanjing Norris-Pharm Technology Co., Ltd
Tel
18652989687
Fax
+86-25-52131256
Email
sales@norris-pharm.com
Country
China
ProdList
8878
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View Lastest Price from 3-Pyridinecarboxamide,2-methyl-(9CI) manufacturers

Dideu Industries Group Limited
Product
3-Pyridinecarboxamide,2-methyl-(9CI) 58539-65-4
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-10-27
Career Henan Chemical Co
Product
3-Pyridinecarboxamide,2-methyl-(9CI) 58539-65-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500kg
Release date
2019-12-31

58539-65-4, 3-Pyridinecarboxamide,2-methyl-(9CI)Related Search:

5H-Pyrrolo[3,4-b]pyridine-5,7(6H)-dione 5-OXO-N-(3-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-(DIMETHYLAMINO)-1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE N-(4-CHLOROBENZYL)-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(TERT-BUTYL)-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-METHYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(4-CHLOROBENZYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-N-(2-PYRIDINYLMETHYL)-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-ALLYL-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-BENZYL-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(2,6-DIMETHYLPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID ALLYLAMIDE 1H-CHROMENO[2,3-B][1,6]NAPHTHYRIDINE-1,11(2H)-DIONE N-(2,4-DIFLUOROPHENYL)-5-OXO-2-(TRIFLUOROMETHYL)-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE N-(4-CHLOROPHENYL)-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 5-OXO-2-(TRIFLUOROMETHYL)-N-[3-(TRIFLUOROMETHYL)BENZYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE

  • 3-Pyridinecarboxamide,2-methyl-(9CI)
  • 2-methylnicotinamide
  • 2-Methyl-3-PyridinecarboxaMide
  • 3-Pyridinecarboxamide, 2-methyl-
  • 3-Pyridinecarboxamide,2-methyl-(9CI) ISO 9001：2015 REACH
  • 2-Methylnicotinamide (~12% inorganics)
  • Olutasidenib Impurity 33
  • 2-Methylnicotinamide, 97%, QA-0097
  • 58539-65-4
  • Pyridines
  • AMIDE