3-Pyridinecarboxamide,2-amino-(9CI)
- Product Name
- 3-Pyridinecarboxamide,2-amino-(9CI)
- CAS No.
- 13438-65-8
- Chemical Name
- 3-Pyridinecarboxamide,2-amino-(9CI)
- Synonyms
- 2-Aminonicotinamide;2-aMino-3-nicotinaMide;2-Aminonicotinamide 98%;2-aMinopyridin-3-carboxaMide;2-Amino-3-pyridinecarboxamide;2-aminopyridine-3-carboxamide;3-Pyridinecarboxamide, 2-amino-;2-Aminopyridine-3-carboxamide 97%;3-Pyridinecarboxamide,2-amino-(9CI);2-Aminopyridine-3-carboxamide, CAS 13438-65-8
- CBNumber
- CB41276877
- Molecular Formula
- C6H7N3O
- Formula Weight
- 137.14
- MOL File
- 13438-65-8.mol
3-Pyridinecarboxamide,2-amino-(9CI) Property
- Melting point:
- 194-200 °C
- Boiling point:
- 328.2±22.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 14.60±0.50(Predicted)
- form
- Solid
- color
- Pale yellow
- InChI
- InChI=1S/C6H7N3O/c7-5-4(6(8)10)2-1-3-9-5/h1-3H,(H2,7,9)(H2,8,10)
- InChIKey
- HTPCDVLWYUXWQR-UHFFFAOYSA-N
- SMILES
- C1(N)=NC=CC=C1C(N)=O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 684090
- Product name
- 2-Aminopyridine-3-carboxamide
- Purity
- 97%
- Packaging
- 1g
- Price
- $70.6
- Updated
- 2025/07/31
- Product number
- A615868
- Product name
- 2-aminonicotinamide
- Packaging
- 500mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA139529
- Product name
- 2-Aminonicotinamide
- Packaging
- 2g
- Price
- $54
- Updated
- 2021/12/16
- Product number
- JK921012
- Product name
- 2-Aminopyridine-3-carboxamide
- Purity
- 98%
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- Y7441
- Product name
- 2-Aminopyridine-3-carboxamide
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
3-Pyridinecarboxamide,2-amino-(9CI) Chemical Properties,Usage,Production
Synthesis
5345-47-1
13438-65-8
The general procedure for the synthesis of 2-aminopyridine-3-carboxamide from 2-aminonicotinic acid was as follows: 2-aminonicotinic acid (1.38 g, 10.0 mmol) was suspended in DMF (50 mL) and HOBt (1.35 g, 10.0 mmol), NH4Cl (1.07 g, 20.0 mmol), EDC-HCl (2.88 g, 15.0 mmol) and triethylamine (2.78 mL, 20.0 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by distillation under reduced pressure and CH2Cl2 (150 mL) and saturated aqueous NaHCO3 solution (150 mL) were added to the residue. The organic phase was separated, dried over Na2SO4 and concentrated under reduced pressure. The residue was purified by rapid chromatography on silica gel (3→5% MeOH-CH2Cl2) to afford 2-aminopyridine-3-carboxamide (1.21 g, 8.85 mmol, 89% yield) in white powder form. The product was characterized by 1H NMR (DMSO-d6) and ESI-MS: 1H NMR (DMSO-d6) δ: 6.55 (1H, dd, J = 7.7,4.8 Hz), 7.17 (2H, s), 7.30 (1H, s), 7.92 (2H, dd, J = 7.7,1.8 Hz), 8.06 (1H, dd, J = 4.8, 1.8 Hz); ESI-MS. 1.8 Hz); ESI-MS m/z: 138 (M + H)+.
References
[1] Bioorganic and Medicinal Chemistry, 2011, vol. 19, # 5, p. 1623 - 1642
[2] Medicinal Chemistry Research, 2011, vol. 20, # 4, p. 408 - 420
[3] Synthesis, 1998, # 10, p. 1467 - 1475
[4] Patent: WO2018/125961, 2018, A1. Location in patent: Page/Page column 103; 104
[5] Monatshefte fuer Chemie, 1900, vol. 21, p. 963
3-Pyridinecarboxamide,2-amino-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Pyridinecarboxamide,2-amino-(9CI) manufacturers
- Product
- 3-Pyridinecarboxamide,2-amino-(9CI) 13438-65-8
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.0% min
- Supply Ability
- 100 tons min
- Release date
- 2021-05-12
- Product
- 3-Pyridinecarboxamide,2-amino-(9CI) 13438-65-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2019-08-30