ChemicalBook > CAS DataBase List > 1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)

1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)

Product Name
1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)
CAS No.
13423-60-4
Chemical Name
1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)
Synonyms
1-phenyl-1,2,4-triazole;1-Phenyl-1H-1,2,4-triazole;1H-1,2,4-Triazole, 1-phenyl-;1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)
CBNumber
CB41281794
Molecular Formula
C8H7N3
Formula Weight
145.16
MOL File
13423-60-4.mol
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1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI) Property

Melting point:
47 °C
Boiling point:
268-270 °C
Density 
1.16±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2.32±0.10(Predicted)
Appearance
Colorless to off-white Solid
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
6173AA
Product name
1-Phenyl-1H-1,2,4-triazole
Packaging
250mg
Price
$131
Updated
2021/12/16
Apolloscientific
Product number
OR962488
Product name
1-Phenyl-1H-1,2,4-triazole
Purity
95%
Packaging
250mg
Price
$150
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-1-HG
Product name
1-Phenyl-1H-1,2,4-triazole
Purity
95%
Packaging
250mg
Price
$240
Updated
2021/12/16
Apolloscientific
Product number
OR962488
Product name
1-Phenyl-1H-1,2,4-triazole
Purity
95%
Packaging
1g
Price
$370
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0984775
Product name
1-PHENYL-1H-1,2,4-TRIAZOLE
Purity
95.00%
Packaging
5MG
Price
$495.3
Updated
2021/12/16
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1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI) Chemical Properties,Usage,Production

Definition

ChEBI: 1-phenyl-1H-1,2,4-triazole is a member of triazoles.

Synthesis Reference(s)

The Journal of Organic Chemistry, 21, p. 1037, 1956 DOI: 10.1021/jo01115a610

Synthesis

288-88-0

591-50-4

13423-60-4

1. CuI (0.10 g, 0.50 mmol), 1,2,4-triazole (0.69 g, 10 mmol), K3PO4 (4.4 g, 20 mmol), iodobenzene (1.4 mL, 12 mmol), and N,N'-dimethylethylenediamine (0.11 mL, 1.0 mmol) were dissolved in DMF (5 mL) under argon protection. Mixed well and degassed. 2. The reaction mixture was heated and stirred at 110°C for 72 hours. 3. 3. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filter cake was washed with ethyl acetate (AcOEt). 4. The solvent was removed by pressurized distillation to give the crude product. 5. The crude product was purified using silica gel column chromatography with heptane/ethyl acetate (7:3, v/v) as eluent. 6. 1-Phenyl-1H-1,2,4-triazole (2a) was isolated in 96% yield as a yellow powder with a melting point of 48 °C (literature value 28-46 °C). 7. The structure of the product was confirmed by 1H NMR and 13C NMR: 1H NMR (CDCl3, 300 MHz) δ 7.42 (m, 1H), 7.53 (m, 2H), 7.71 (m, 2H), 8.15 (s, 1H), 8.74 (s, 1H); 13C NMR (CDCl3, 75 MHz) δ 120.1 (2CH) , 128.3 (CH), 129.9 (2CH), 137.1 (C), 140.9 (CH), 152.7 (CH).

References

[1] Journal of the American Chemical Society, 2007, vol. 129, # 45, p. 13879 - 13886
[2] Journal of Organic Chemistry, 2007, vol. 72, # 8, p. 2737 - 2743
[3] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 19, p. 6355 - 6363
[4] RSC Advances, 2014, vol. 4, # 83, p. 44105 - 44116
[5] Journal of Organic Chemistry, 2004, vol. 69, # 17, p. 5578 - 5587

1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI) Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI) Suppliers

China 44 Europe 1 Germany 1 India 1 South Korea 1 United States 5 Global 53
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13423-60-4, 1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)Related Search:

3-Hydroxy-1-phenyl-1,2,4-triazole 4-(1,2,4-TRIAZOL-1-YL)PHENOL Triazophos 5-METHYL-3-(METHYLTHIO)-1,4-DIPHENYL-1H-1,2,4-TRIAZOLIUM IODIDE METHYL 3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXYLATE N'-(2,4-DICHLOROPHENYL)-2-[(1-PHENYL-1H-1,2,4-TRIAZOL-3-YL)OXY]ETHANIMIDOHYDRAZIDE 1-[3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDINYL]-4-[4-(1-PHENYL-1H-1,2,4-TRIAZOL-5-YL)PHENYL]PIPERAZINE N-(4-FLUOROPHENYL)-3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXAMIDE 3-[(1-PHENYL-1H-1,2,4-TRIAZOL-3-YL)OXY]-2-BUTANONE 3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXYLIC ACID 4-[(4-METHOXYBENZYLIDENE)AMINO]-1-(4-METHYLPHENYL)-4H-1,2,4-TRIAZOL-1-IUM METHANESULFONATE 1,4-DIPHENYL-1H-1,2,4-TRIAZOL-4-IUM-3-THIOLATE 3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)-N-[3-(TRIFLUOROMETHYL)PHENYL]BENZENECARBOXAMIDE N-(3-CHLOROPHENYL)-3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXAMIDE N-(2-CHLOROPHENYL)-3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXAMIDE 1,4,5-TRIPHENYL-4H-1,2,4-TRIAZOL-1-IUM-3-THIOLATE 3-NITRO-4-(1H-1,2,4-TRIAZOL-1-YL)BENZENECARBOXAMIDE 3-(BENZYLTHIO)-1,4-DIPHENYL-1H-1,2,4-TRIAZOL-4-IUM CHLORIDE

  • 1H-1,2,4-Triazole,1-phenyl-(6CI,7CI,8CI,9CI)
  • 1-Phenyl-1H-1,2,4-triazole
  • 1H-1,2,4-Triazole, 1-phenyl-
  • 1-phenyl-1,2,4-triazole
  • 13423-60-4
  • TRIAZOLE