1H-Benzimidazole,2-chloro-4-methyl-(9CI)
- Product Name
- 1H-Benzimidazole,2-chloro-4-methyl-(9CI)
- CAS No.
- 15965-57-8
- Chemical Name
- 1H-Benzimidazole,2-chloro-4-methyl-(9CI)
- Synonyms
- 2-Chloro-4-methylbenzimidazole;2-Chloro-7-methyl-1H-benzimidazole;2-CHLORO-4-METHYL-1H-BENZIMIDAZOLE;2-CHLORO-4-METHYL-1H-BENZOIMIDAZOLE;1H-Benzimidazole, 2-chloro-7-methyl-;2-Chloro-7-Methyl-1H-benzo[d]iMidazole;2-Chloro-4-Methyl-1H-benzo[d]iMidazole;1H-Benzimidazole,2-chloro-4-methyl-(9CI)
- CBNumber
- CB41292426
- Molecular Formula
- C8H7ClN2
- Formula Weight
- 166.61
- MOL File
- 15965-57-8.mol
1H-Benzimidazole,2-chloro-4-methyl-(9CI) Property
- Boiling point:
- 339.9±35.0 °C(Predicted)
- Density
- 1.351
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 10.26±0.30(Predicted)
- Appearance
- Light yellow to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C384573
- Product name
- 2-Chloro-4-methyl-1H-benzimidazole
- Packaging
- 100mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- 8038AA
- Product name
- 2-Chloro-4-methyl-1H-benzo[d]imidazole
- Packaging
- 100mg
- Price
- $172
- Updated
- 2021/12/16
- Product number
- 8038AA
- Product name
- 2-Chloro-4-methyl-1H-benzo[d]imidazole
- Packaging
- 250mg
- Price
- $243
- Updated
- 2021/12/16
- Product number
- HCH0357766
- Product name
- 2-CHLORO-4-METHYL-1H-BENZIMIDAZOLE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $497.3
- Updated
- 2021/12/16
- Product number
- SC-41026
- Product name
- 2-CHLORO-4-METHYL-1H-BENZO[D]IMIDAZOLE
- Purity
- 95%
- Packaging
- 1g
- Price
- $550
- Updated
- 2021/12/16
1H-Benzimidazole,2-chloro-4-methyl-(9CI) Chemical Properties,Usage,Production
Synthesis
19190-68-2
15965-57-8
Step A: Synthesis of 2-chloro-4-methyl-1H-benzo[d]imidazole To 4-methyl-1H-benzo[d]imidazol-2(3H)-one (1.5 g, 10 mmol) was added trichlorophosphorus (POCl3, 19 mL). The reaction mixture was heated to 135 °C and kept for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the excess phosphorous trichloride was removed under vacuum. The residue was carefully diluted with water and subsequently slowly neutralized with saturated sodium bicarbonate (NaHCO3) solution to a pH of about 7-8. The mixture was extracted with ethyl acetate (2 x 150 mL) and the organic phases were combined. The organic phase was dried with anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to give the crude product. The crude product was purified by fast column chromatography (Biotage system) to afford 2-chloro-7-methyl-1H-benzo[d]imidazole (1.1 g, 6.3 mmol, 62% yield) as a light yellow powder. Mass spectrum (LC/MS) retention time (R.T.) = 2.61 min; [M+H]+ = 166.93.
References
[1] Patent: WO2016/73407, 2016, A1. Location in patent: Page/Page column 56
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 15, p. 7188 - 7211
[3] Patent: US5273975, 1993, A
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 18, p. 5010 - 5014
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 4, p. 1071 - 1074
1H-Benzimidazole,2-chloro-4-methyl-(9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Benzimidazole,2-chloro-4-methyl-(9CI) manufacturers
- Product
- 1H-Benzimidazole,2-chloro-4-methyl-(9CI) 15965-57-8
- Price
- US $6.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 1kg, 5kg, 50kg
- Release date
- 2020-01-09