PE 22-28

Product Name: PE 22-28
CAS No.: 1801959-12-5
Chemical Name: PE 22-28
Synonyms: PE 22-28;L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-;(2S,5S,11S,14S,17S)-11-((1H-Indol-3-yl)methyl)-20-amino-2-(3-guanidinopropyl)-14-(hydroxymethyl)-5-isobutyl-17-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosan-1-oic acid
CBNumber: CB412950414
Molecular Formula: C35H55N11O9
Formula Weight: 773.88
MOL File: 1801959-12-5.mol

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PE 22-28 Property

Density: 1.44±0.1 g/cm3(Predicted)
pka: 3.34±0.10(Predicted)
form: Solid
color: White to off-white
Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg
InChIKey: CMNBQRXBBJQIOA-YIHYGEMESA-N
SMILES: C(O)(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC1C2=C(C=CC=C2)NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](C(C)C)NC(=O)CN

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Hazard and Precautionary Statements (GHS)

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PE 22-28 Chemical Properties,Usage,Production

Uses

PE 22-28 is a TREK-1 inhibitor with IC50 value of 0.12 nM. PE 22-28 also is a 7 amino-acid peptide that is used as a core sequence for preparing analogs by chemical modifications and also by substitution of amino-acids. PE 22-28 can be used for the research of depression[1].

in vivo

PE 22-28 (i.p.; 3.0μg/kg) shows antidepressant property^[1].

Animal Model:	Nave male C57Bl/6J mice^[1]
Dosage:	3.0μg/kg
Administration:	Intraperitoneal
Result:	Showed a significant reduction of the immobility time, reduced significantly the latency to eat the food pellet, induced neurogenesis and improved the action duration.

References

[1] Alaeddine Djillani, et al. Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity. Front Pharmacol. 2017 Sep 12;8:643. DOI:10.3389/fphar.2017.00643

PE 22-28 Preparation Products And Raw materials

Raw materials

Preparation Products

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PE 22-28 Suppliers

China 38 Global 38

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13770331960
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16059
Advantage: 64

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14917
Advantage: 59

Shanghai Haozhixiang Biotechnology Co., Ltd

Tel: 526763801 13301653310
Fax: +86-21-51619052
Email: 526763801@qq.com
Country: China
ProdList: 9445
Advantage: 55

Chengdu Youngshe Chemical Co., Ltd.

Tel: +86-17380623303 +86-17380623303;
Fax: 028-62328193
Email: Caroline@youngshechem.com
Country: China
ProdList: 4801
Advantage: 58

Hangzhou Peptidego Biotech Co.,Ltd.

Tel: 0571-87213919
Email: Eric@peptidego.com
Country: China
ProdList: 7617
Advantage: 58

Hangzhou Go Top Peptide Biotech

Tel: 15397062932
Email: sales1@gotopbio.com
Country: China
ProdList: 2982
Advantage: 58

Hubei Zhongshan Medical Technology Co., Ltd

Tel: 13437178871
Fax: 3443707954
Email: w13397111514@163.com
Country: China
ProdList: 828
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24960
Advantage: 58

Hangzhou Sinoda Pharmaceutical Technology Co. LTD

Tel: 0571-87213919 17306812703
Email: 3007955328@qq.com
Country: China
ProdList: 7189
Advantage: 58

Combio (Suzhou) Ltd.

Tel: 17751201929
Email: office@combiosz.com
Country: China
ProdList: 2986
Advantage: 58

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View Lastest Price from PE 22-28 manufacturers

Hebei Lutong Import and Export Co., Ltd

Product: PE-22-28 1801959-12-5
Price: US $66.00/box
Min. Order: 1box
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-09-24

Ningbo Qingteng Plastic Cost.,Ltd.

Product: PE 22-28 1801959-12-5
Price: US $10.00-7.00/VIAL
Min. Order: 10VIAL
Purity: 99.9
Supply Ability: 20000
Release date: 2025-07-23

Shenzhen Aoxi Technology Co., Ltd.

Product: PE-22-28 1801959-12-5
Price: US $30.00-10.00/kit
Min. Order: 1kit
Purity: 99%
Supply Ability: 10000kits
Release date: 2025-03-19

1801959-12-5, PE 22-28Related Search:

THR-ARG-SER-ALA-TRP LEU-VALORPHIN-ARG H-THR-ARG-SER-ALA-TRP-NH2 ZIP (SCRAMBLED) TRITRPTICIN

L-Arginine, glycyl-L-valyl-L-seryl-L-tryptophylglycyl-L-leucyl-

(2S,5S,11S,14S,17S)-11-((1H-Indol-3-yl)methyl)-20-amino-2-(3-guanidinopropyl)-14-(hydroxymethyl)-5-isobutyl-17-isopropyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazaicosan-1-oic acid

PE 22-28

1801959-12-5