Pinealon
- Product Name
- Pinealon
- CAS No.
- 175175-23-2
- Chemical Name
- Pinealon
- Synonyms
- Pinealon;Pinealon (Brain);Pinealon 5mg 10mg;Peptides Lyophilized;Pinealon Bioregulator;Peptides Lyophilized Powder;L-Arginine, L-α-glutamyl-L-α-aspartyl-
- CBNumber
- CB412960538
- Molecular Formula
- C15H26N6O8
- Formula Weight
- 418.4
- MOL File
- 175175-23-2.mol
Pinealon Property
- Density
- 1.63±0.1 g/cm3(Predicted)
- pka
- 3.15±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Sequence
- H-Glu-Asp-Arg-OH
Pinealon Chemical Properties,Usage,Production
Description
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.
Uses
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].
benefits
EDR (Glu-Asp-Arg, Pinealon), a tripeptide isolated from the polypeptide neuroprotective drug Cortexin, is one of the neuroprotective arginine-containing peptides. Oral administration of Pinealon revealed its effectiveness in correcting cerebral dysfunctions in older age groups. The EDR peptide contributed to neuronal apoptosis reduction, improvement of memory, attention and cognitive functions, acceleration of perceptual-motor responses, an increased mental performance, and decreased central nervous system (CNS) ageing in the elderly[1].
in vitro
Pinealon (10, 50, 100 nM; 30 min) in a dose-dependent manner prevents an increase in the ROS accumulation induced by ouabain in cerebellar granule cells.
Pinealon (10 nM; 0, 2.5, 5, 10, 20, 30 min) suppresses the activation of ERK 1/2 in rat cerebellar granule cells exposed to 500 mM homo-cysteine (HC).
in vivo
Pinealon (50, 100, 200 ng/kg; Injection, for 5 days) shows a dose-dependent effect on the maintenance of a previously acquired skill in rats[2].
Pinealon (10 μg/kg; daily for 5 days) protects the rat offspring from prenatal hyperhomocysteinemia[3].
| Animal Model: | 200-250 g, white male rats[2] |
| Dosage: | 50, 100, 200 ng/kg |
| Administration: | Injection; for 5 days |
| Result: | Showed dose-dependent effects on the maintenance of a previously acquired skill in the Morris maze. |
| Animal Model: | 180-200 g, Female Wistar rats[3] |
| Dosage: | 10 μg/kg |
| Administration: | I.p.; daily for 5 days |
| Result: | Protected the rat offspring from prenatal hyperhomocysteinemia. |
References
[1] Vladimir Khavinson. “EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease.” Molecules (2020).
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View Lastest Price from Pinealon manufacturers
- Product
- Pinealon 175175-23-2
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-12-05
- Product
- Pinealon 175175-23-2
- Price
- US $1.00/kg
- Min. Order
- 0.000165kg
- Purity
- 99%
- Supply Ability
- 200kg
- Release date
- 2025-11-12
- Product
- Pinealon
- Price
- US $0.00/box
- Min. Order
- 1box
- Purity
- 99%
- Supply Ability
- 10 tons
- Release date
- 2025-10-13