ChemicalBook > CAS DataBase List > N-hexanoyl-L-homoserine lactone

N-hexanoyl-L-homoserine lactone

Product Name
N-hexanoyl-L-homoserine lactone
CAS No.
147852-83-3
Chemical Name
N-hexanoyl-L-homoserine lactone
Synonyms
C6-HSL;C6HSL,HHL;Hexanoyl-L-hoMoserine lactone;N-hexanoyl-L-homoserine lactone;N-[(3S)-2-oxooxolan-3-yl]hexanamide;C6-HSL, N-Hexanoyl-L-hoMoserine lactone;(S)-N-(2-Oxotetrahydrofuran-3-yl)hexanamide;N-Hexanoyl-L-homoserine lactone, ≥96% (HPLC);N-[(3S)-Tetrahydro-2-oxo-3-furanyl]hexanamide;Hexanamide, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
CBNumber
CB41312724
Molecular Formula
C10H17NO3
Formula Weight
199.25
MOL File
147852-83-3.mol
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N-hexanoyl-L-homoserine lactone Property

Melting point:
132-134 °C(Solv: dichloromethane (75-09-2))
Boiling point:
434.0±34.0 °C(Predicted)
Density 
1.08±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMF: 30 mg/ml; DMSO: 30 mg/ml; PBS (pH 7.2): 10 mg/ml
form 
A crystalline solid
pka
15.03±0.20(Predicted)
color 
White to light yellow
optical activity
[α]/D -32±3°, c = 0.2 in methanol
BRN 
8143287
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
56395
Product name
N-Hexanoyl-L-homoserine lactone
Purity
≥96% (HPLC)
Packaging
10mg
Price
$213
Updated
2024/03/01
Sigma-Aldrich
Product number
56395
Product name
N-Hexanoyl-L-homoserine lactone
Purity
≥96% (HPLC)
Packaging
50mg
Price
$830
Updated
2024/03/01
Cayman Chemical
Product number
10007896
Product name
N-hexanoyl-L-Homoserine lactone
Purity
≥95%
Packaging
5mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
10007896
Product name
N-hexanoyl-L-Homoserine lactone
Purity
≥95%
Packaging
10mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
10007896
Product name
N-hexanoyl-L-Homoserine lactone
Purity
≥95%
Packaging
25mg
Price
$100
Updated
2024/03/01
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N-hexanoyl-L-homoserine lactone Chemical Properties,Usage,Production

Description

Quorum sensing is a regulatory system used by bacteria for controlling gene expression in response to increasing cell density. A promising field of study involves controlling bacterial infections by quenching their quorum sensing systems. The expression of specific target genes, such as transcriptional regulators belonging to the LuxIR family of proteins, is coordinated by synthesis of diffusible acylhomoserine lactone (AHL) molecules. N-hexanoyl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing, controlling gene expression, and affecting cellular metabolism. The diverse applications of this molecule include regulation of virulence in general and in cystic fibrosis, infection prevention, slime and biofilm reduction in commercial agriculture and aquaculture industries, food spoilage prevention, and septicemia in fish.

Uses

Hexanoyl-L-homoserine lactone is an active quorum sensing modulator first recognised in Rhizobium leguminosarum. Hexanoyl-L-homoserine lactone and other acylhomoserine lactones have been detected in hundreds of bacterial species and, while the homologues vary between species and strains, the homoserine lactones are the major chemical modulators of within and between cell communication and regulation. The most significant variable defining the function of the homoserine lactone is the length of the acyl chain, with shorter chains displaying opposing actions to the longer chains.

Definition

ChEBI: N-[(3s)-2-Oxotetrahydrofuran-3-Yl]hexanamide is a N-acyl-amino acid.

General Description

N-Hexanoyl-L-homoserine lactone is produced and utilized by various Gram-negative bacteria as a quorum sensing (QS) signal molecule.

Biochem/physiol Actions

N-Hexanoyl-L-homoserine lactone is a member of N-acyl-homoserine lactone family. N-Acylhomoserine lactones (AHL) regulate gene expression in gram-negative bacteria, such as Echerichia and Salmonella, and are involved in quorum sensing, cell to cell communication among bacteria; for reviews see. Bacterial intercellular communication has become a target for the development of new anti-virulence drugs, and a research focus for the prevention of biofilm formation.

N-hexanoyl-L-homoserine lactone Preparation Products And Raw materials

Raw materials

Preparation Products

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147852-83-3, N-hexanoyl-L-homoserine lactoneRelated Search:

L-Tryptophan L-Methionine L(+)-Arginine

  • C6-HSL, N-Hexanoyl-L-hoMoserine lactone
  • Hexanoyl-L-hoMoserine lactone
  • N-hexanoyl-L-homoserine lactone
  • C6HSL,HHL
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  • N-[(3S)-Tetrahydro-2-oxo-3-furanyl]hexanamide
  • N-[(3S)-2-oxooxolan-3-yl]hexanamide
  • Hexanamide, N-[(3S)-tetrahydro-2-oxo-3-furanyl]-
  • (S)-N-(2-Oxotetrahydrofuran-3-yl)hexanamide
  • N-Hexanoyl-L-homoserine lactone, ≥96% (HPLC)
  • Inhibitor,Bacterial,NhexanoylLHomoserine lactone,N hexanoyl L Homoserine lactone,inhibit
  • 147852-83-3