AIT 082

Product Name: AIT 082
CAS No.: 138117-50-7
Chemical Name: AIT 082
Synonyms: AIT 082;Leteprinim;AIT 082 acid;NEOTROFIN; AIT-082;4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoic acid;Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-
CBNumber: CB41313145
Molecular Formula: C15H13N5O4
Formula Weight: 327.29
MOL File: 138117-50-7.mol

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AIT 082 Property

Melting point:: 319-321°.
Boiling point:: 825.1±55.0 °C(Predicted)
Density: 1.57±0.1 g/cm3(Predicted)
pka: 4.31±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: API0011770
Product name: LETEPRINIM
Purity: 95.00%
Packaging: 5MG
Price: $496.94
Updated: 2021/12/16

DC Chemicals

Product number: DC9798
Product name: Leteprinim
Purity: >98%
Packaging: 250mg
Price: $850
Updated: 2021/12/16

DC Chemicals

Product number: DC9798
Product name: Leteprinim
Purity: >98%
Packaging: 1g
Price: $1700
Updated: 2021/12/16

DC Chemicals

Product number: DC9798
Product name: Leteprinim
Purity: >98%
Packaging: 100mg
Price: $450
Updated: 2021/12/16

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AIT 082 Chemical Properties,Usage,Production

Uses

Leteprinim (AIT-082 free acid), a purine analog, is a neuroprotective agent and cognitive enhancer. Leteprinim is a hypoxanthine derivative neurotrophic agent. Leteprinim can induce brain-derived neurotrophic factor (BDNF) mRNA production following spinal cord lesions, and nerve growth factor (NGF) mRNA production in basal forebrain. Leteprinim reduces glutamate toxicity in cultured hippocampal neurons. Leteprinim increases heme-oxygenase 1 and 2 mRNA levels that play role in cellular defense against reactive oxygen species[1][2][3][4].

Definition

ChEBI: Leteprinim is an amidobenzoic acid.

in vivo

Leteprinim (30 or 60 mg/kg, i.p., for 7 days) protect rats against Kainate (12 mg/kg) induced excitotoxicity of hippocampal neurons^[1].
Leteprinim (60 mg/kg, i.p.) enhances working memory in young and aged mice^[3].
Leteprinim (60 mg/kg; i.p.; single dosage) significantly reduces the number of apoptotic neurons in hypoxic-ischemic brain injury rat pups^[4].

Animal Model:	Wistar rat pups (hypoxic-ischemic brain injury induced by permanent unilateral carotid ligation)^[4]
Dosage:	60 mg/kg
Administration:	IP; single dosage
Result:	The number of preserved neurons was significantly high in CA1, CA3 regions of hippocampus and dentate gyrus in the left hemispheres when compared with the saline-treated group. In the right hemisphere, neuronal densities of CA1, CA2, CA3 regions of hippocampus and dentate gyrus were significantly high in neotrofin treatment group when compared with the group given saline.

References

[1] Di Iorio P, et al. AIT-082 is neuroprotective against kainate-induced neuronal injury in rats. Exp Neurol. 2001 Jun;169(2):392-9. DOI:10.1006/exnr.2001.7654
[2] Lahiri DK, et al. Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin. Ann N Y Acad Sci. 2000 Apr;903:387-93. DOI:10.1111/j.1749-6632.2000.tb06390.x
[3] Glasky AJ, et al. Effect of AIT-082, a purine analog, on working memory in normal and aged mice. Pharmacol Biochem Behav. 1994 Feb;47(2):325-9. DOI:10.1016/0091-3057(94)90017-5
[4] Gencp?nar P, et al. Effects of neotrofin on neonatal hypoxic ischemic brain injury. Neurosci Lett. 2011 Nov 14;505(2):205-10. DOI:10.1016/j.neulet.2011.10.027

AIT 082 Preparation Products And Raw materials

Raw materials

Preparation Products

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AIT 082 Suppliers

China 22 United States 3 Global 25

LGM Pharma

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Shanghai Apichemical CO.,LTD

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Shanghai Han-Xiang Chemical Co., Ltd.

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TargetMol Chemicals Inc.

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Absin Bioscience Inc.

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138117-50-7, AIT 082Related Search:

AIT 082 NEOTROFIN

AIT 082

4-[3-(6-oxo-3H-purin-9-yl)propanoylamino]benzoic acid

Leteprinim

AIT 082 acid

NEOTROFIN; AIT-082

Benzoic acid, 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]-

138117-50-7