verrucarin J
- Product Name
- verrucarin J
- CAS No.
- 4643-58-7
- Chemical Name
- verrucarin J
- Synonyms
- Verrucrin J;verrucarin J;Verrucarin J DISCONTINUED;Verrucarin A, 2',3'-didehydro-2'-deoxy-, (2'E)-
- CBNumber
- CB41313695
- Molecular Formula
- C27H32O8
- Formula Weight
- 484.54
- MOL File
- 4643-58-7.mol
verrucarin J Property
- alpha
- D19 +54° (benzene); D22 +20 ± 2° (c = 1.011 in chloroform)
- Boiling point:
- 735.4±60.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- solubility
- Dichloromethane: Soluble
DMSO: Soluble
Ethanol: Soluble
Methanol: Soluble - form
- powder
- color
- White
Safety
- RIDADR
- 3172
- HazardClass
- 6.1(a)
- PackingGroup
- I
- HS Code
- 2941900000
N-Bromosuccinimide Price
- Product number
- MTB0000555
- Product name
- VERRUCARIN J
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $2895.72
- Updated
- 2021/12/16
verrucarin J Chemical Properties,Usage,Production
Uses
Verrucarin J can be used in biological study of characteristics of toxigenic properties of Myrothecium cinctum and Myrothecium commune.
Definition
ChEBI: Verrucarin j is a trichothecene.
in vivo
Verrucarin J (0.5?mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model[2].
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis[5].
| Animal Model: | 6-8 weeks old BALB/c athymic nude mice (nu/nu) with pCMV/HCT 116 and AKT/HCT 116 xenografts[2] |
| Dosage: | 0.5?mg/kg body weight |
| Administration: | i.p. for 4 weeks |
| Result: | Reduced the expression of prosurvival markers pAKT, Notch1, p65, and Ki67 in all tumors. |
| Animal Model: | Female nude nu/nu (5 to 6 weeks old) mice with A2780 xenografts[5] |
| Dosage: | 0.1, 0.5, 2.0 mg/kg (vehicle: 10% DMSO, 90% glyceryl trioctanoate) |
| Administration: | i.p. for three weeks after 10 days of injection of A2780 cells |
| Result: | Reduced tumor weight (32% lower compared to control), and reduced visible metastasis in 0.1 mg/kg. Showed a significant reduction in visible peritoneal tumors (61% lower compared to control group) and highly reduced visible metastasis in 0.5 mg/kg. Reduced ovarian tumor weight by 71% compared to vehicle in 0.5 mg/kg. In lethal dose 2 mg/kg, mice sick with a swollen belly, body fluid and subsequently died within 3 treatments. |
References
[1] MINH VAN NGUYEN. Curvicollide D, a new modified γ-lactone from the culture broth of Albifimbria verrucaria and its antifungal activity against plant pathogenic fungi[J]. Journal of Antibiotics, 2022, 75 9: 514-518. DOI: 10.1038/s41429-022-00541-7
[2] KAREN UDOH. Targeting of Lung Cancer Stem Cell Self-Renewal Pathway by a Small Molecule Verrucarin J.[J]. Stem Cell Reviews and Reports, 2019, 15 4: 601-611. DOI: 10.1007/s12015-019-09874-7
[3] DEEKSHA PAL. Suppression of Notch1 and AKT mediated epithelial to mesenchymal transition by Verrucarin J in metastatic colon cancer.[J]. ACS Biomaterials Science & Engineering, 2018: 798. DOI: 10.1038/s41419-018-0810-8
verrucarin J Preparation Products And Raw materials
Raw materials
Preparation Products
verrucarin J Suppliers
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- +1-631-485-4226
- Fax
- 1-631-614-7828
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- Country
- United States
- ProdList
- 19552
- Advantage
- 58
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- +17819995354
- marketing@targetmol.com
- Country
- United States
- ProdList
- 19962
- Advantage
- 58