mersacidin
- Product Name
- mersacidin
- CAS No.
- 128104-18-7
- Chemical Name
- mersacidin
- Synonyms
- mersacidin;L-Isoleucinamide, L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-phenylalanyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-L-prolylglycylglycylglycylglycyl-L-valyl-L-cysteinyl-(2S,3S)-2-amino-3-mercaptobutanoyl-L-leucyl-(2S,3S)-2-amino-3-mercaptobutanoyl-2,3-didehydroalanyl-L-α-glutamyl-L-cysteinyl...
- CBNumber
- CB41317532
- Molecular Formula
- C80H120N20O21S4
- Formula Weight
- 1826.19
- MOL File
- 128104-18-7.mol
mersacidin Property
- Boiling point:
- 2116.4±65.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- pka
- 4.48±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- API0025373
- Product name
- MERSACIDIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.58
- Updated
- 2021/12/16
mersacidin Chemical Properties,Usage,Production
Definition
ChEBI: A type-B lantibiotic containing 3-methyllanthionine and S-(2-aminovinyl)-3-methylcysteine residues and four intra-chain thioether bridges. It is obtained from Bacillus sp. HIL Y-85,54728 and is active in vivo ag inst methicillin-resistant Staphylococcus aureus (MRSA).
Synthesis
Mersacidin is a polycyclic lantibiotic characterized by thioether-bridged rings formed by unusual amino acids like lanthionine. While naturally produced via ribosomal synthesis and post-translational modification, Solid-Phase Peptide Synthesis (SPPS) is the primary chemical route for preparing analogues. The main challenge in SPPS is the selective formation of these bridges, often addressed by either incorporating pre-formed lanthionine building blocks or inducing intramolecular Michael addition on the linear peptide. This chemical approach allows for systematic modification to create novel analogues with enhanced biological activity.
mersacidin Preparation Products And Raw materials
Raw materials
Preparation Products
mersacidin Suppliers
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- info@creative-peptides.com
- Country
- United States
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