CREBtide
- Product Name
- CREBtide
- CAS No.
- 149155-45-3
- Chemical Name
- CREBtide
- Synonyms
- CREBtide TFA;CREBtide [KRREILSRRPSYR] - 5 mg;L-Arginine, L-lysyl-L-arginyl-L-arginyl-L-α-glutamyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-L-arginyl-L-prolyl-L-seryl-L-tyrosyl-
- CBNumber
- CB41319905
- Molecular Formula
- C73H129N29O19
- Formula Weight
- 1716.99
- MOL File
- 149155-45-3.mol
CREBtide Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- Sequence
- Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0045222
- Product name
- CREBtide
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-0045222
- Product name
- CREBtide
- Packaging
- 10mg
- Price
- $440
- Updated
- 2021/12/16
- Product number
- CS-0045222
- Product name
- CREBtide
- Packaging
- 1mg
- Price
- $80
- Updated
- 2021/12/16
CREBtide Chemical Properties,Usage,Production
Uses
CREBtide is a CREB (cAMP response element binding protein)-like peptide. CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA and PKC substrate.
Biological Activity
CREBtide is a synthetic 13 amino acid peptide that acts as a PKA substrate.
in vitro
delta-CREB is a spliced variant of cAMP response element binding protein (CREB). CREBtide (KRREILSRRPSYR), a synthetic peptide based on the phosphorylation sequence in delta-CREB. delta-CREB and CREBtide are tested as substrates of cAMP-dependent protein kinase (cAK). The apparent K m of CREBtide phosphorylation by cAK is 3.9 μM, which is 10-fold lower than that of Kemptide (K m =39 μM), the synthetic peptide substrate most often employed for cAK measurement. The V max values are 12.4 mumol/(min.mg) for CREBtide and 9.8 mumol/(min.mg) for Kemptide. The apparent K m of CREBtide phosphorylation by cGMP-dependent protein kinase (cGK) is 2.9 μM and the V max value is 3.2 mumol/(min.mg). Both delta -CREB and CREBtide are phosphorylated at a much slower rate by cGK as compared with cAK, implying that the high cAK/cGK specificity exhibits by delta-CREB is retained by the peptide.
target
PKA
References
[1] Wu J, et al. A microPLC-based approach for determining kinase-substrate specificity. Assay Drug Dev Technol. 2007 Aug;5(4):559-66. DOI:10.1089/adt.2007.072
[2] Colbran JL, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82. DOI:10.1139/o92-174
[3] Harum KH, et al. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology. 2001 Jan 23;56(2):207-14. DOI:10.1212/wnl.56.2.207
[4] Peng J, et al. Protein kinase C-α signals P115RhoGEF phosphorylation and RhoA activation in TNF-α-induced mouse brain microvascular endothelial cell barrier dysfunction. J Neuroinflammation. 2011 Apr 8;8:28. DOI:10.1186/1742-2094-8-28
CREBtide Preparation Products And Raw materials
Raw materials
Preparation Products
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