marcfortine A

Product Name: marcfortine A
CAS No.: 75731-43-0
Chemical Name: marcfortine A
Synonyms: UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
CBNumber: CB41323193
Molecular Formula: C28H35N3O4
Formula Weight: 477.602
MOL File: 75731-43-0.mol

More

Less

marcfortine A Property

Melting point:: 245 °C
Boiling point:: 660.6±55.0 °C(Predicted)
Density: 1.33±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Methanol: soluble
form: A solid
pka: 12.05±0.60(Predicted)

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 23486
Product name: Marcfortine A
Purity: ≥99%
Packaging: 1mg
Price: $340
Updated: 2024/03/01

Cayman Chemical

Product number: 23486
Product name: Marcfortine A
Purity: ≥99%
Packaging: 5mg
Price: $1523
Updated: 2024/03/01

Usbiological

Product number: M2374-75
Product name: Marcfortine A
Packaging: 1mg
Price: $588
Updated: 2021/12/16

TRC

Product number: M197305
Product name: MarcfortineA
Packaging: 2.5mg
Price: $625
Updated: 2021/12/16

More

Less

marcfortine A Chemical Properties,Usage,Production

Description

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD₉₉ = 0.06 μg/ml) and inhibits motility of adult worms (EC₅₀ = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED₉₅s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α₃ subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Uses

Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.

Uses

Marcfortine A is an indole alkaloid isolated from Aspergillus and Pencillium species.

References

[1] J. POLONSKY. Isolation and structure (X-ray analysis) of marcfortine A, a new alkaloid from Penicillium roqueforti[J]. Journal of The Chemical Society, Chemical Communications, 1980, 278 1: 601-602. DOI: 10.1039/c39800000601
[2] ROBERT J. CAPON. Aspergillicins A—E: Five Novel Depsipeptides from the Marine-Derived Fungus Aspergillus carneus.[J]. ChemInform, 2003, 34 40. DOI: 10.1002/chin.200340185
[3] S S JOHNSON. Interrelationships among physicochemical properties, absorption and anthelmintic activities of 2-desoxoparaherquamide and selected analogs.[J]. Journal of veterinary pharmacology and therapeutics, 2004, 27 3: 169-181. DOI: 10.1111/j.1365-2885.2004.00577.x
[4] ZINSER E W, Mark L. Wolf, Susan J. Alexander-Bowman, et al. Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals[J]. Journal of veterinary pharmacology and therapeutics, 2002, 25 4: 241-250. DOI: 10.1046/j.1365-2885.2002.00423.x

marcfortine A Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

marcfortine A Suppliers

China 17 United Kingdom 1 United States 5 Global 23

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
Advantage: 58

Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6777
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Country: United States
ProdList: 32435
Advantage: 58

BOC Sciences

Tel: +1-631-485-4226
Fax: 1-631-614-7828
Email: inquiry@bocsci.com
Country: United States
ProdList: 19552
Advantage: 58

Meng Cheng Technology (Shanghai) Co., LTD

Tel: 400-820-6829
Email: sales@mitachieve.com
Country: China
ProdList: 8860
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24961
Advantage: 58

Shanghai Saikerui Biotechnology Co. , Ltd.

Tel: 021-58000709 15900491054
Email: info@scrbio.com
Country: China
ProdList: 9881
Advantage: 58

75731-43-0, marcfortine ARelated Search:

C-[1-(4-METHOXY-PHENYL)-CYCLOPENTYL]-METHYLAMINE N-CYCLOPENTYL-N-METHYL-2-PIPERIDINEMETHANAMINE 2H-Indol-2-one,1,3-dihydro-6,7-dihydroxy-(9CI) ALPHA-PROPYLDOPACETAMIDE 1,1-DIMETHYL-2-PIPERIDIN-1-YL-ETHYLAMINE CHEMBRDG-BB 4017497 CHEMBRDG-BB 4011370 [1-(3,4-DIMETHOXYPHENYL)CYCLOPENTYL]METHANAMINE CHEMBRDG-BB 4011371 2,5-Diazabicyclo[2.2.2]octane 2H-Pyrido[1,2-a]pyrazin-1(6H)-one,hexahydro-(6CI,8CI,9CI) (1S,4S)-2,5-DIAZABICYCLO(2.2.2)OCTANE marcfortine A

marcfortine A

UK 111866

Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-

75731-43-0