KP 136
- Product Name
- KP 136
- CAS No.
- 76239-32-2
- Chemical Name
- KP 136
- Synonyms
- KP 136;AL-136;KP-136,KP136;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)coumarin;8-Hexyloxy-3-(1H-tetrazol-5-yl)-2H-chromen-2-one;8-(Hexyloxy)-3-(1H-tetrazol-5-yl)-2H-1-benzopyran-2-one;2H-1-Benzopyran-2-one, 8-(hexyloxy)-3-(2H-tetrazol-5-yl)-
- CBNumber
- CB41332245
- Molecular Formula
- C16H18N4O3
- Formula Weight
- 314.343
- MOL File
- 76239-32-2.mol
KP 136 Property
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
N-Bromosuccinimide Price
- Product number
- PXT0001268
- Product name
- 8-N-HEXYLOXY-3-(1H-TETRAZOL-5-YL)COUMARIN
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.89
- Updated
- 2021/12/16
KP 136 Chemical Properties,Usage,Production
Uses
KP136 (AL136) is an orally effective antiallergic agent. The IC50 is 76.1 μg/mL for histamine release and 63 ug/mL for degranulation[1].
in vivo
C4C at 0.2 mg/kg produces an equipotent effect to 1 mg/kg KP136 (KP-136) or 5 mg/kg DSCG. However, C4C is less effective by the oral route because it only produces a maximum inhibition of about 35% even at the high dose of 100 mg/kg, whereas KP136 shows an overt inhibitory effect of about 66% at the oral dose of 2 mg/kg. On the other hand, KP136 (1 mg/kg, i.v.) also remarkably inhibits 5-h homologous PCA, having an activity similar to that of C4C[1].
References
[1] Kuriyama K, et al. Antiallergic effects of 4-[2-oxo-3-(1H-tetrazol-5-yl)-2H-chromen-8-yloxy]-bu tyric acid. Jpn J Pharmacol. 1989 Jun;50(2):111-8. DOI:10.1254/jjp.50.111
KP 136 Preparation Products And Raw materials
Raw materials
Preparation Products
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