(3β)-3-[(4-Fluorobenzoyl)oxy]lup-20(29)-en-28-oic acid

(3β)-3-[(4-Fluorobenzoyl)oxy]lup-20(29)-en-28-oic acid Property

Boiling point:

630.1±35.0 °C(Predicted)

Density 

1.15±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

solubility 

DMF: 10 mg/ml
DMSO: 2 mg/ml
Ethanol: 2 mg/ml

pka

4.60±0.70(Predicted)

Hazard and Precautionary Statements (GHS)

(3β)-3-[(4-Fluorobenzoyl)oxy]lup-20(29)-en-28-oic acid Chemical Properties,Usage,Production

Uses

ZM522 is a CD73 inhibitor with an IC50 value of 0.56 μM. ZM522 effectively increases the levels of interferon-γ (INF-γ) and enhances immune activity by regulating the activation status of T cells. ZM522 holds promise for research in the fields of immunology and cancer therapy[1].

References

[1] Zhang Y, et al. Application of a fluorine strategy in the lead optimization of betulinic acid to the discovery of potent CD73 inhibitors. Steroids. 2022 Dec;188:109112. DOI:10.1016/j.steroids.2022.109112