INS 365

ChemicalBook > CAS DataBase List > INS 365

Product Name: INS 365
CAS No.: 211427-08-6
Chemical Name: INS 365
Synonyms: D03864;INS 365;Diquafosol sodium;Diquafosol tetrasodium;Diquafosol sodium (jan);Dexamethoxol tetrasodium;Diquafosol Tetrasodium CRS;Diquafosol Tetrasodium Salt;Diquafosol Impurity 7(UP4U);Diquafosol tetrasodium (usan)
CBNumber: CB41347117
Molecular Formula: C18H27N4NaO23P4
Formula Weight: 814.3
MOL File: 211427-08-6.mol

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INS 365 Property

storage temp.: Store at -20°C
solubility: DMSO:1.0(Max Conc. mg/mL);1.14(Max Conc. mM)
Water:100.0(Max Conc. mg/mL);113.86(Max Conc. mM)
form: A solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H228Flammable solid

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

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N-Bromosuccinimide Price

ChemScene

Product number: CS-6370
Product name: Diquafosoltetrasodium
Purity: >99.0%
Packaging: 100mg
Price: $672
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159346
Product name: Diquafosol tetrasodium
Packaging: 500mg
Price: $1500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159346
Product name: Diquafosol tetrasodium
Packaging: 1g
Price: $2000
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159346
Product name: Diquafosol tetrasodium
Packaging: 2g
Price: $2500
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD159346
Product name: Diquafosol tetrasodium
Packaging: 5G
Price: $3500
Updated: 2021/12/16

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INS 365 Chemical Properties,Usage,Production

Description

Diquafosol (INS-365) was approved in Japan in 2010 as a 3% ophthalmic solution for treatment of dry eye disease. Clinical diagnosis of dry eye is difficult because the condition presents a variety of symptoms. Treatment options include tear supplements (lubricants), anti-inflammatory drugs (e.g., cyclosporine eye drops or steroid eye drops), and tear retention devices. Diquafosol is a unique agent for the treatment of dry eye in that it acts as a P2Y2 purinergic receptor agonist with the ability to activate this receptor on the ocular surface and stimulate water, lipid, and mucin secretion. Diquafosol is metabolized by phosphodiesterases to UTP, UDP, UMP, and uridine. Diquafosol has been well tolerated in clinical trials, with side effects being local to the ocular surface.In addition,no serious ocular or systemic adverse drug reactions were found during the clinical trials.

Originator

Inspire Pharmaceuticals (United States)

Uses

Enhancement of mucosal hydration in the treatment of chronic dry eye (P2Y2 receptor antagonist).

brand name

Diquas

Clinical Use

Diquafosol tetrasodium was approved in April 2010 as Diquas ® ophthalmic solution 3% for the treatment of dry eye syndrome and launched in Japan by Santen Pharmaceuticals. Diquafosol tetrasodium was originally discovered by Inspire Pharmaceuticals. In 2001, it was licensed to Santen for co-development and commercialization in Asian countries, and co-developed in collaboration with Allergan for the countries outside of Asia. In the U.S., diquafosol tetrasodium was submitted for a New Drug Application (NDA) as Prolacria ®(2% ophthalmic formulation) in June 2003. However, it is still in Phase III clinical development for dry eye syndrome. Diquafosol tetrasodium, also known as INS- 365, is a P2Y2 receptor agonist, which activates P2Y2 receptor on the ocular surface, leading to rehydration through activation of the fluid pump mechanism of the accessory lacrimal glands on the conjunctival surface.

Synthesis

The large-scale synthesis route of diquafosol tetrasodium is described in Scheme 4. Commercially available uridine 5?ˉ-diphosphate disodium salt (21) was transformed into the corresponding tributylamine salt by ion exchange chromatography on Dowex 50 using Bu3NH+ phase, and then dimerized by means of CDI in DMF at 50 oC. The crude product was purified by Sephadex DEAE column followed by ion exchange using a Dowex 50W resin in Na+ mode. The onepot process provided diquafosol tetrasodium (IV) in 25% yield.

INS 365 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from INS 365 manufacturers

Guangzhou Tosun Pharmaceutical Limited

Product: Diquafosol Impurity 11 211427-08-6
Price: US $0.00/mg
Min. Order: 1mg
Purity: 99.88%
Supply Ability: 50mg
Release date: 2023-06-27

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Diquafosol Sodium 211427-08-6
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 10kg
Release date: 2021-09-13

Zhuozhou Wenxi import and Export Co., Ltd

Product: Diquafosol 211427-08-6
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-11

211427-08-6, INS 365Related Search:

Diquafosol Impurity 10 Uridine UTP cytidine 3',5'-diphosphate Diquafosol Impurity 1 Diquafosol Impurity 3 Diquafosol Diquafosol Impurity 12 DUTP, 100MM SOLUTION URIDINE 5'-TRIPHOSPHATE TRISODIUM SALT Diquafosol Impurity 2 uridine 5'-tetraphosphate Iodixanol Ramelteon Tafluprost

INS 365

D03864

Diquafosol sodium

Diquafosol sodium (jan)

Diquafosol tetrasodium

Diquafosol tetrasodium (usan)

Diquafosol Impurity 7(UP4U)

[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl] [[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate

Diquafosol Tetrasoudium or P1,P4-Di(Uridine-5′-Tetraphosphate)

Diquafosol Tetrasodium Salt

Diquafosol tetrasodium impurity

Diquafosol tetrasodium intermediate

P1,P4-Diuridine 5'-tetraphosphate tetrasodium salt

Diquafosol Tetrasodium (INS365)

Diquafosol Sodium Reference Substance

TIANFUCHEM--211427-08-6 INS 365

Dexamethoxol tetrasodium

Diquafosol Tetrasodium CRS

211427-08-6

C18H26N4O23P44Na