clomesone
- Product Name
- clomesone
- CAS No.
- 88343-72-0
- Chemical Name
- clomesone
- Synonyms
- SRI-6155;clomesone;NSC-338947;Chlorethyl SOSO;Clomesone, 10 mM in DMSO;2-Chloroethyl methanesulfonylmethanesulfonate;(Methylsulfonyl)methanesulfonic acid 2-chloroethyl ester;Methanesulfonic acid, 1-(methylsulfonyl)-, 2-chloroethyl ester
- CBNumber
- CB41352791
- Molecular Formula
- C4H9ClO5S2
- Formula Weight
- 236.695
- MOL File
- 88343-72-0.mol
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
clomesone Chemical Properties,Usage,Production
Uses
Clomesone (NSC 338947) is a compound with antitumor activity. Clomesone induces the formation of cross-links between DNA strands in cell lines. Clomesone is inactive against most human colorectal cancer solid tumor cell lines in vitro, has no significant activity against mouse tumors in vivo, and is accompanied by bone marrow suppression. Its pharmacokinetic behavior indicates that it cannot reach effective concentrations at the tumor site.
References
[1] Pre-clinical evaluation of a novel chloroethylating agent, Clomesone DOI:10.1038/bjc.1993.85
[2] M E Dolan, et al. Effect of O6-methylguanine on DNA interstrand cross-link formation by chloroethylnitrosoureas and 2-chloroethyl(methylsulfonyl)methanesulfonate. Cancer Res. 1988 Jul 1;48(13):3603-6. PMID:2837318
clomesone Preparation Products And Raw materials
Raw materials
Preparation Products
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