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safracin B

Product Name
safracin B
CAS No.
87578-99-2
Chemical Name
safracin B
Synonyms
safracin B;Antibiotic EM 5519;Antibiotic Y 16482-alpha;2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide;Propanamide, 2-amino-N-[[(6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-
CBNumber
CB41353031
Molecular Formula
C28H36N4O7
Formula Weight
540.61
MOL File
87578-99-2.mol
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safracin B Property

Boiling point:
755.1±60.0 °C(Predicted)
Density 
1.41±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 20 mg/ml)
pka
9.75±0.70(Predicted)
form 
solid
color 
Yellow-green
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0025385
Product name
SAFRACIN B
Purity
95.00%
Packaging
250MG
Price
$3072.3
Updated
2021/12/16
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safracin B Chemical Properties,Usage,Production

Description

Safracin B (87578-99-2) is a novel antibiotic of the saframycin family produced by?Pseudomonas fluorescens.1?Safracin B displays antitumor activity against L1210 and P388 leukemias and B16 melanoma. Compared with safracin A, the toxic and effective doses were much lower. Safracin B also prolonged the life of tumor-bearing mice to a greater extent than safracin A.2

Uses

Safracin B is a new antibiotics from the family of Safracin produced by Pseudomonas fluorescens A2-2. Safracin B is an antibiotic that exhibits anti-tumor properties.

in vivo

Safracin B (0.005-5 mg/kg/day; for 9 days) prolongs the life span of tumor-bearing mice and shows antitumor activity against L1210 and P388 leukemias and B16 melanoma in Female BALB/c x DBA/2 F1 (CD2F1) mice weighing 19-24 g[2].
The LD50 is 7.3 mg/kg with safracin B in normal CD2F1 mice by ip administration[2].

References

[1] Y IKEDA. Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.[J]. Journal of Antibiotics, 1983, 36 10: 1279-1283. DOI:10.7164/antibiotics.36.1279
[2] T OKUMOTO. Activity of safracins A and B, heterocyclic quinone antibiotics, on experimental tumors in mice.[J]. Journal of Antibiotics, 1985, 38 6: 767-771. DOI:10.7164/antibiotics.38.767

safracin B Preparation Products And Raw materials

Raw materials

Preparation Products

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safracin B Suppliers

China 20 India 2 United States 6 Global 28
INTERCHEMIE NANJING PHARMATECH CO., LTD
Tel
13656237714 13656237714;
Fax
0512-65852853
Email
xiaokunfu@kyyykj.com
Country
China
ProdList
295
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9274
Advantage
55
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
BOC Sciences
Tel
+1-631-485-4226
Fax
1-631-614-7828
Email
inquiry@bocsci.com
Country
United States
ProdList
19552
Advantage
58
Beijing xinyanhui pharmaceutical research and development co., LTD
Tel
13969155946
Email
1461866103@qq.com
Country
China
ProdList
16111
Advantage
58
Shanghai Jiegu Biotechnology Co., Ltd.
Tel
021-51698675
Email
sales@jiejiegroup.com
Country
China
ProdList
8020
Advantage
58
Zhejiang Huida Biotech Co., LTD
Tel
0571-89903882 18679456698
Email
mingxinzhu@huidabiotech.com
Country
China
ProdList
2975
Advantage
58
Fuxin Pharmaceutical
Tel
021-50872116 13611907556
Fax
021-31300828
Email
contact@fuxinpharm.com
Country
China
ProdList
1611
Advantage
58
Hubei Chenxin Pharmaceutical Co., Ltd.
Tel
17362916295 17362916295;
Fax
QQ:840947394
Email
w17362916295@163.com
Country
China
ProdList
3004
Advantage
58

87578-99-2, safracin BRelated Search:

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  • safracin B
  • 2-Amino-N-[(6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-epimino-5H-isoquino[3,2-b][3]benzazocin-9-yl)methyl]propionamide
  • Propanamide, 2-amino-N-[[(6S,7S,9R,14aS,15R)-6,7,9,10,13,14,14a,15-octahydro-1,7-dihydroxy-2,11-dimethoxy-3,12,16-trimethyl-10,13-dioxo-6,15-imino-5H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-, (2S)-
  • Antibiotic EM 5519
  • Antibiotic Y 16482-alpha
  • 87578-99-2
  • C28H36N4O7