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peptide 78

Product Name
peptide 78
CAS No.
132116-62-2
Chemical Name
peptide 78
Synonyms
peptide 78;L-Asparagine, L-threonyl-L-methionyl-L-arginyl-L-lysyl-L-prolyl-L-arginyl-L-serylglycyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-valyl-L-alanyl- (9CI)
CBNumber
CB41354689
Molecular Formula
C62H107N23O21S
Formula Weight
1542.72
MOL File
132116-62-2.mol
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peptide 78 Property

storage temp. 
Store at -20°C
form 
Solid
color 
White to off-white
Water Solubility 
Water : 100 mg/mL (64.82 mM; Need ultrasonic)
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Hazard and Precautionary Statements (GHS)

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peptide 78 Chemical Properties,Usage,Production

Biological Activity

Peptide 78, a chemotactic cytokine, a 78 amino acid protein member of the IL-8 or C-X-C chemokine supergene family. ENA-78 plays an important role in the elicitation of predominantly neutrophils (PMNs) into the joints of rheumatoid arthritis (RA)[1]. Peptide 78, a potent PMN chemotaxin, in the conditioned medium of human pulmonary epithelial cells (A549) stimulated with TNF-α (20 ng/mL) or IL-1β (10 ng/mL). Peptide 78 is an 8.3-kD protein with 78 amino acids containing 4 cysteines positioned identically to those of IL-8 and its homologues. Peptide 78 belongs to a supergene family that includes platelet factor-4, platelet basic protein, and its cleavage products (connective tissue activating peptide-III, β-thromboglobulin, and interferon-γ-inducible protein, macrophage inflammatory protein-2α, and macrophage inflammatory protein-2β)[1]. Peptide 78 shares several properties of PMN activation similar to either NAP-2 or LL-8. Peptide 78 stimulation of PMNs results in significant chemotactic activity, release of elastase from cytochalasin-B-pretreated cells, and the induction of free, cytosolic calcium release. Peptide 78 aids in the recruitment of PMNs into inflamed joints of RA. Peptide 78 represents one of the most abundant chemokines present in RA synovial fluid.Peptide 78 in rheumatoid arthritis synovial fluids is biologically active. Peptide 78 appears to account for almost half of the RA synovial fluid PMN chemotactic activity in vitro[1].

References

[1]. A E Koch, et al. Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritis. J Clin Invest. 1994 Sep;94(3):1012-8.

peptide 78 Preparation Products And Raw materials

Raw materials

Preparation Products

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peptide 78 Suppliers

Nanjing Leon Biological Technology Co., Ltd.
Tel
17705183659
Fax
84523390
Email
sales@njleonbiotech.com
Country
China
ProdList
5501
Advantage
55
Nanjing Peptide Biotech Ltd.
Tel
025-025-58361106-805-805 13082558573
Fax
025-58361106-806
Email
liugang@njpeptide.com
Country
China
ProdList
9980
Advantage
55
Hangzhou Peptidego Biotech Co.,Ltd.
Tel
0571-87213919
Fax
0571-87213919
Email
Eric@peptidego.com
Country
China
ProdList
6968
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58
Hangzhou Sinoda Pharmaceutical Technology Co. LTD
Tel
0571-87213919 17306812703
Email
3007955328@qq.com
Country
China
ProdList
6659
Advantage
58

132116-62-2, peptide 78Related Search:


  • peptide 78
  • L-Asparagine, L-threonyl-L-methionyl-L-arginyl-L-lysyl-L-prolyl-L-arginyl-L-serylglycyl-L-asparaginyl-L-prolyl-L-α-aspartyl-L-valyl-L-alanyl- (9CI)
  • 132116-62-2
  • C62H107N23O21S